Selective Pressure of Antibiotic Pollution on Bacteria of Importance to Public Health.
Background: Many bacteria of clinical importance survive and may grow in different environments. Antibiotic pollution may exert on them a selective pressure leading to an increase in the prevalence of resistance. Objectives: In this study we sought to determine whether environmental concentrations o...
| Publicado en: | Environmental Health Perspectives Vol. 120; no. 8; pp. 1100 - 1107 |
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| Autores principales: | , , |
| Formato: | research tables/charts Journal Article |
| Publicado: |
National Institute of Environmental Health Sciences
Aug2012
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| Acceso en línea: | Ver este registro en EBSCOhost |
| fields | @attributes: recordID: 1 pdfLink: plink: https://search.ebscohost.com/login.aspx?direct=true&db=ccm&AN=104493789&site=ehost-live header: @attributes: shortDbName: ccm uiTerm: 104493789 longDbName: CINAHL Complete uiTag: AN controlInfo: bkinfo: dissinfo: jinfo: jid: 00916765 3B5 jtl: Environmental Health Perspectives issn: 00916765 maglogo: N pubinfo: dt: Aug2012 vid: 120 iid: 8 pid: 56539 pub: National Institute of Environmental Health Sciences place: Research Triangle Park, North Carolina artinfo: ui: 104493789 78433162 10.1289/ehp.1104650 NLM22571927 104493789 ppf: 1100 ppct: 7 formats: fmt: @attributes: type: P tig: atl: Selective Pressure of Antibiotic Pollution on Bacteria of Importance to Public Health. aug: au: Tello, Alfredo Austin, Brian Telfer, Trevor C. affil: Institute of Aquaculture, University of Stirling, Stirling, Scotland, United Kingdom sug: subj: Antibiotics Drug Resistance, Microbial Air Pollutants, Environmental Environmental Monitoring Bacteria Models, Statistical Descriptive Statistics Natural Environment Ciprofloxacin Analysis Erythromycin Analysis Tetracycline Analysis Genetics Evolution Prevalence Confidence Intervals Data Analysis Software Regression Maximum Likelihood Funding Source ab: Background: Many bacteria of clinical importance survive and may grow in different environments. Antibiotic pollution may exert on them a selective pressure leading to an increase in the prevalence of resistance. Objectives: In this study we sought to determine whether environmental concentrations of antibiotics and concentrations representing action limits used in environmental risk assessment may exert a selective pressure on clinically relevant bacteria in the environment. Methods: We used bacterial inhibition as an assessment end point to link antibiotic selective pressures to the prevalence of resistance in bacterial populations. Species sensitivity distributions were derived for three antibiotics by fitting log-logistic models to end points calculated from minimum inhibitory concentration (MIC) distributions based on worldwide data collated by the European Committee on Antimicrobial Susceptibility Testing (EUCAST). To place bacteria represented in these distributions in a broader context, we performed a brief phylogenetic analysis. The potentially affected fraction of bacterial genera at measured environmental concentrations of antibiotics and environmental risk assessment action limits was used as a proxy for antibiotic selective pressure. Measured environmental concentrations and environmental risk assessment action limits were also directly compared to wild-type cut-off values. Results: The potentially affected fraction of bacterial genera estimated based on antibiotic concentrations measured in water environments is ? 7%. We estimated that measured environmental concentrations in river sediments, swine feces lagoons, liquid manure, and farmed soil inhibit wild-type populations in up to 60%, 92%, 100%, and 30% of bacterial genera, respectively. At concentrations used as action limits in environmental risk assessment, erythromycin and ciprofloxacin were estimated to inhibit wild-type populations in up to 25% and 76% of bacterial genera. Conclusions: Measured environmental concentrations of antibiotics, as well as concentrations representing environmental risk assessment action limits, are high enough to exert a selective pressure on clinically relevant bacteria that may lead to an increase in the prevalence of resistance. pubtype: Academic Journal doctype: research tables/charts Journal Article ougenre: Article language: English refInfo: holdings: @attributes: islocal: N |
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