Prenatal and Early Childhood Exposure to Tetrachloroethylene and Adult Vision.
Background: Tetrachloroethylene (PCE; or perchloroethylene) has been implicated in visual impairments among adults with occupational and environmental exposures as well as children born to women with occupational exposure during pregnancy. Objectives: Using a population-based retrospective cohort st...
| Publicado en: | Environmental Health Perspectives Vol. 120; no. 9; pp. 1327 - 1333 |
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| Autores principales: | , , , , , , , , |
| Formato: | research tables/charts Journal Article |
| Publicado: |
National Institute of Environmental Health Sciences
Sep2012
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| Acceso en línea: | Ver este registro en EBSCOhost |
| fields | @attributes: recordID: 1 pdfLink: plink: https://search.ebscohost.com/login.aspx?direct=true&db=ccm&AN=104505951&site=ehost-live header: @attributes: shortDbName: ccm uiTerm: 104505951 longDbName: CINAHL Complete uiTag: AN controlInfo: bkinfo: dissinfo: jinfo: jid: 00916765 3B5 jtl: Environmental Health Perspectives issn: 00916765 maglogo: N pubinfo: dt: Sep2012 vid: 120 iid: 9 pid: 56539 pub: National Institute of Environmental Health Sciences place: Research Triangle Park, North Carolina artinfo: ui: 104505951 79835156 10.1289/ehp.1103996 NLM22784657 104505951 ppf: 1327 ppct: 6 formats: fmt: @attributes: type: P tig: atl: Prenatal and Early Childhood Exposure to Tetrachloroethylene and Adult Vision. aug: au: Getz, Kelly D. Janulewicz, Patricia A. Rowe, Susannah Weinberg, Janice M. Winter, Michael R. Martin, Brett R. Vieira, Veronica M. White, Roberta F. Aschengrau, Ann affil: Department of Epidemiology, Boston University School of Public Health, Boston, Massachusetts, USA; sug: subj: Environmental Exposure In Infancy and Childhood Water Supply Hydrocarbons, Chlorinated Adverse Effects Vision Disorders Etiology Color Vision Defects Etiology Human Massachusetts Retrospective Design Prospective Studies Confidence Intervals Odds Ratio Occupational Exposure In Pregnancy Adult Male Female Descriptive Statistics Vision Tests Algorithms Data Analysis Software Prenatal Exposure Delayed Effects Fetus Pregnancy Infant, Newborn Infant Child Clinical Assessment Tools Smoking Funding Source Adult: 19-44 years Fetus, conception to birth Infant, Newborn: birth-1 month Infant: 1-23 months Child: 6-12 years Male Female ab: Background: Tetrachloroethylene (PCE; or perchloroethylene) has been implicated in visual impairments among adults with occupational and environmental exposures as well as children born to women with occupational exposure during pregnancy. Objectives: Using a population-based retrospective cohort study, we examined the association between prenatal and early childhood exposure to PCE-contaminated drinking water on Cape Cod, Massachusetts, and deficits in adult color vision and contrast sensitivity. Methods: We estimated the amount of PCE that was delivered to the family residence from participants' gestation through 5 years of age. We administered to this now adult study population vision tests to assess acuity, contrast sensitivity, and color discrimination. Results: Participants exposed to higher PCE levels exhibited lower contrast sensitivity at intermediate and high spatial frequencies compared with unexposed participants, although the differences were generally not statistically significant. Exposed participants also exhibited poorer color discrimination than unexposed participants. The difference in mean color confusion indices (CCI) was statistically significant for the Farnsworth test but not Lanthony's D-15d test [Farnsworth CCI mean difference = 0.05, 95% confidence interval (CI): 0.003, 0.10; Lanthony CCI mean difference = 0.07, 95% CI: -0.02, 0.15]. Conclusions: Prenatal and early childhood exposure to PCE-contaminated drinking water may be associated with long-term subclinical visual dysfunction in adulthood, particularly with respect to color discrimination. Further investigation of this association in similarly exposed populations is necessary. pubtype: Academic Journal doctype: research tables/charts Journal Article ougenre: Article language: English refInfo: holdings: @attributes: islocal: N |
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