Histopathologic Characteristics of Sentinel Lymph Node Biopsy in Breast Carcinoma: Uludag( University Faculty of Medicine Experience.
Objective: Nowadays, sentinel lymph node (SLN) biopsy is a standard approach giving information about status of the axillary lymph nodes. Several factors affect metastasis to SLN. In our case, we aimed to indicate histopathological parameters that affect SLN and non-sentinel lymph node (n-SLN) metas...
| Publicado en: | Turkiye Klinikleri Journal of Medical Sciences Vol. 31; no. 6; pp. 1324 - 1330 |
|---|---|
| Autores principales: | , , , |
| Formato: | pictorial research tables/charts Journal Article |
| Publicado: |
Turkiye Klinikleri
Nov/Dec2011
|
| Acceso en línea: | Ver este registro en EBSCOhost |
| fields | @attributes: recordID: 1 pdfLink: plink: https://search.ebscohost.com/login.aspx?direct=true&db=ccm&AN=104507188&site=ehost-live header: @attributes: shortDbName: ccm uiTerm: 104507188 longDbName: CINAHL Complete uiTag: AN controlInfo: bkinfo: dissinfo: jinfo: jid: 13000292 1VOP jtl: Turkiye Klinikleri Journal of Medical Sciences issn: 13000292 maglogo: N pubinfo: dt: Nov/Dec2011 vid: 31 iid: 6 pid: 67298 pub: Turkiye Klinikleri artinfo: ui: 104507188 104507188 2011440518 10.5336/medsci.2010-16770 104507188 ppf: 1324 ppct: 6 formats: fmt: @attributes: type: P tig: atl: Histopathologic Characteristics of Sentinel Lymph Node Biopsy in Breast Carcinoma: Uludag( University Faculty of Medicine Experience. aug: au: Elezoglu, Bahar Tolunay, Sahsine Tasdelen, Ismet Gökgöz, Sehsuvar sug: subj: Breast Neoplasms Diagnosis Sentinel Lymph Node Biopsy Academic Medical Centers Adult Aged Aged, 80 and Over Data Analysis Software Descriptive Statistics Female Fisher's Exact Test Human Mann-Whitney U Test Middle Age Pearson's Correlation Coefficient Turkiye Adult: 19-44 years Aged: 65+ years Aged, 80 & over Middle Aged: 45-64 years Female ab: Objective: Nowadays, sentinel lymph node (SLN) biopsy is a standard approach giving information about status of the axillary lymph nodes. Several factors affect metastasis to SLN. In our case, we aimed to indicate histopathological parameters that affect SLN and non-sentinel lymph node (n-SLN) metastasis, the importance of frozen section to determine metastasis and immunohistochemistry method for histopathological examinations. Material and Methods: In Uludag University Faculty of Medicine, 265 cases who had SLN biopsies were retrospectively examined. Frozen sections, permanent sections and sections with immunohistochemistry were found out from the archieve. Then, preparations were re-examined by expert pathologists on breast pathology. Results: The mean age of the cases was 53 years. The most frequently observed tumor type was invasive ductal carcinoma. Most of the cases had nuclear grade 2. One hundred cases are diagnosed as malignant. As a result of implementation of serial sections and immunohistochemistry to 12 cases without metastasis, macro-metastasis in four cases, micro-metastasis in six cases and finally isolated tumour cells in two cases were determined. In primary breast tumor, the presence of venous/vascular invasion (p= 0.021), lymphatic invasion (p< 0.001), increased primary tumor diameter (p= 0.001) and increased age (p= 0.026) increased SLN metastasis. In primary breast tumor, the presence of perineural invasion (p= 0.033) and lymphatic invasion (p= 0.045), increased tumor diameter (p= 0.001), and increased number of positive SLNs (p= 0.015) caused an increase in n-SLN metastasis. Conclusion: SLN biopsy is a simple and reliable method. In our study, we found statistically significant results between SLN metastasis and age, primary tumor diameter, lymphatic invasion and venous/vascular invasion. Besides, statistically significant relationships were found between n-SLN metastasis and primary tumor diameter, perineural invasion and lymphatic invasion as well. Intraoperative analysis of SLN is very important for staging of breast carcinoma and prognosis. Moreover, accuracy of diagnosis increases with the applications of serial section and immunohistochemical method. pubtype: Academic Journal doctype: pictorial research tables/charts Journal Article ougenre: Article language: Turkish refInfo: holdings: @attributes: islocal: N |
|---|