Bisphenol A Exposure Is Associated with in Vivo Estrogenic Gene Expression in Adults.
BACKGROUND: Bisphenol A (BPA) is a synthetic estrogen commonly used in polycarbonate plastic and resin-lined food and beverage containers. Exposure of animal and cell models to doses of BPA below the recommended tolerable daily intake (TDI) of 50 μg/kg/day have been shown to alter specific estrogen-...
| Publicado en: | Environmental Health Perspectives Vol. 119; no. 12; pp. 1788 - 1794 |
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| Autores principales: | , , , , , , , , , , , |
| Formato: | research tables/charts Journal Article |
| Publicado: |
National Institute of Environmental Health Sciences
Dec2011
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| Acceso en línea: | Ver este registro en EBSCOhost |
| fields | @attributes: recordID: 1 pdfLink: plink: https://search.ebscohost.com/login.aspx?direct=true&db=ccm&AN=104513058&site=ehost-live header: @attributes: shortDbName: ccm uiTerm: 104513058 longDbName: CINAHL Complete uiTag: AN controlInfo: bkinfo: dissinfo: jinfo: jid: 00916765 3B5 jtl: Environmental Health Perspectives issn: 00916765 maglogo: N pubinfo: dt: Dec2011 vid: 119 iid: 12 pid: 56539 pub: National Institute of Environmental Health Sciences place: Research Triangle Park, North Carolina artinfo: ui: 104513058 71025046 10.1289/ehp.1103809 NLM21831745 PMC3261992 104513058 ppf: 1788 ppct: 6 formats: fmt: @attributes: type: P tig: atl: Bisphenol A Exposure Is Associated with in Vivo Estrogenic Gene Expression in Adults. aug: au: Melzer, David Harries, Lorna Cipelli, Riccardo Henley, William Money, Cathryn McCormack, Paul Young, Anita Guralnik, Jack Ferrucci, Luigi Bandinelli, Stefania Corsi, Anna Maria Galloway, Tamara affil: Epidemiology and Public Health, Peninsula College of Medicine and Dentistry, University of Exeter, Exeter, United Kingdom sug: subj: Phenols Poisoning Environmental Exposure Gene Expression Drug Effects Human In Vivo Studies Male Leukocytes Metabolism Descriptive Statistics Phenols Urine Confidence Intervals Linear Regression Polymerase Chain Reaction Environmental Pollutants Poisoning Prospective Studies Italy Risk Factors Adult Middle Age Aged Data Analysis Software Funding Source Adult: 19-44 years Middle Aged: 45-64 years Aged: 65+ years Male ab: BACKGROUND: Bisphenol A (BPA) is a synthetic estrogen commonly used in polycarbonate plastic and resin-lined food and beverage containers. Exposure of animal and cell models to doses of BPA below the recommended tolerable daily intake (TDI) of 50 μg/kg/day have been shown to alter specific estrogen-responsive gene expression, but this has not previously been shown in humans. OBJECTIVE: We investigated associations between BPA exposure and in vivo estrogenic gene expression in humans. METHODS: We studied 96 adult men from the InCHIANTI population study and examined in vivo expression of six estrogen receptor, estrogen-related receptor, and androgen receptor genes in peripheral blood leukocytes. RESULTS: The geometric mean urinary BPA concentration was 3.65 ng/mL [95% confidence interval (CI): 3.13, 4.28], giving an estimated mean excretion of 5.84 μg/day (95% CI: 5.00, 6.85), significantly below the current TDI. In age-adjusted models, there were positive associations between higher BPA concentrations and higher ESR2 [estrogen receptor 2 (ER beta)] expression (unstandardized linear regression coefficient = 0.1804; 95% CI: 0.0388, 0.3221; p = 0.013) and ESRRA (estrogen related receptor alpha) expression (coefficient = 0.1718; 95% CI: 0.0213, 0.3223; p = 0.026): These associations were little changed after adjusting for potential confounders, including obesity, serum lipid concentrations, and white cell subtype percentages. Upper-tertile BPA excretors (urinary BPA > 4.6 ng/mL) had 65% higher mean ESR2 expression than did lower-tertile BPA excretors (0-2.4 ng/mL). CONCLUSIONS: Because activation of nuclear-receptor-mediated pathways by BPA is consistently found in laboratory studies, such activation in humans provides evidence that BPA is likely to function as a xenoestrogen in this sample of adults. pubtype: Academic Journal doctype: research tables/charts Journal Article ougenre: Article language: English refInfo: holdings: @attributes: islocal: N |
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