Low frequency oscillations of response time explain parent ratings of inattention and hyperactivity/impulsivity.
Greater intra-subject variability (ISV) in response time is a heritable endophenotype of attention-deficit/hyperactivity disorder (ADHD). Spontaneous low frequency oscillations (LFO: 0.01-0.1 Hz) observed in brain functional magnetic resonance signals might account for such behavioral variability. R...
| Publicado en: | European Child & Adolescent Psychiatry Vol. 21; no. 2; pp. 101 - 110 |
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| Autores principales: | , , , , , , |
| Formato: | research tables/charts Journal Article |
| Publicado: |
Springer Nature
Feb2012
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| Acceso en línea: | Ver este registro en EBSCOhost |
| fields | @attributes: recordID: 1 pdfLink: plink: https://search.ebscohost.com/login.aspx?direct=true&db=ccm&AN=104513322&site=ehost-live header: @attributes: shortDbName: ccm uiTerm: 104513322 longDbName: CINAHL Complete uiTag: AN controlInfo: bkinfo: dissinfo: jinfo: jid: 10188827 EJ3 jtl: European Child & Adolescent Psychiatry issn: 10188827 maglogo: N pubinfo: dt: Feb2012 vid: 21 iid: 2 pid: 237 pub: Springer Nature place: New York, New York artinfo: ui: 104513322 71107440 10.1007/s00787-011-0237-6 NLM22287035 104513322 ppf: 101 ppct: 9 formats: fmt: @attributes: type: P tig: atl: Low frequency oscillations of response time explain parent ratings of inattention and hyperactivity/impulsivity. aug: au: Mairena, María Martino, Adriana Domínguez-Martín, Cristina Gómez-Guerrero, Lorena Gioia, Gerard Petkova, Eva Castellanos, F. affil: Phyllis Green and Randolph Cōwen Institute for Pediatric Neuroscience, NYU Child Study Center, 215 Lexington Avenue, 14th Floor New York 10016 USA sug: subj: Attention Deficit Hyperactivity Disorder Task Performance and Analysis Magnetic Resonance Imaging Human Child Behavior Rating Scales Scales Questionnaires Sampling Methods Descriptive Statistics DSM Multiple Regression Funding Source Child: 6-12 years ab: Greater intra-subject variability (ISV) in response time is a heritable endophenotype of attention-deficit/hyperactivity disorder (ADHD). Spontaneous low frequency oscillations (LFO: 0.01-0.1 Hz) observed in brain functional magnetic resonance signals might account for such behavioral variability. Recently, we demonstrated that ISV in response time (RT) explained ratings of ADHD symptoms. Building on this finding, here we hypothesized that LFO in RT time series would explain these ratings, both independently and in addition to RT coefficient of variation (CV). To measure RT LFO, we applied Morlet wavelet transform to the previously collected RT data. Our community sample consisted of 98 children (including 66 boys, mean age 9.9 ± 1.4 years), who completed four computer Tasks of Executive Control. Conners' Parent Rating Scale ratings were obtained. RT LFO of three tasks significantly explained ratings of inattention, hyperactivity and three global Conners' subscales. In addition, RT LFO during two tasks that included an inhibitory component increased the proportions of variance explained in subscales of both inattention and hyperactivity/impulsivity, beyond the effects of RT-CV. Three specific low frequency bands (Slow-5: 0.01-0.027 Hz; Slow-4: 0.027-0.073 Hz; Slow-3: 0.073-0.20 Hz) were strongly related to the ADHD scales. We conclude that RT LFO predict dimensional ratings of ADHD symptoms both independently and in addition to RTCV. Results suggest that frequency analyses are a suitable methodology to link behavioral responses to putative underlying physiological processes. pubtype: Academic Journal doctype: research tables/charts Journal Article ougenre: Article language: English refInfo: holdings: @attributes: islocal: N |
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