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IMMUNE DEPOSITS IN CUTANEOUS LESIONS OF WEGENER'S GRANULOMATOSIS: PREDICTOR OF AN ACTIVE DISEASE.

A retrospective analysis was conducted of eight cases of Wegener's granulomatosis (WG), who presented with cutaneous lesions. The clinical, immunopathologic and histopathologic features of the cutaneous lesions were reviewed. Antineutrophil cytoplasmic antibody (ANCA) status of the patients was esta...

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Published in:Indian Journal of Dermatology Vol. 56; no. 6; pp. 758 - 763
Main Authors: Chhabra, Seema, Minz, Ranjana W., Rani, Lekha, Sharma, Nidhi, Sakhuja, Vinay, Sharma, Aman
Format: case study pictorial research tables/charts Journal Article
Published: Wolters Kluwer India Pvt Ltd Nov/Dec2011
Online Access:View this record in EBSCOhost
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      dt: Nov/Dec2011
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      pub: Wolters Kluwer India Pvt Ltd
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        atl: IMMUNE DEPOSITS IN CUTANEOUS LESIONS OF WEGENER'S GRANULOMATOSIS: PREDICTOR OF AN ACTIVE DISEASE.
      aug:
        au:
          Chhabra, Seema
          Minz, Ranjana W.
          Rani, Lekha
          Sharma, Nidhi
          Sakhuja, Vinay
          Sharma, Aman
        affil: Department of Immunopathology, Postgraduate Institute of Medical Education and Research, Chandigarh (UT), India
      sug:
        subj:
          Granulomatosis with Polyangiitis Diagnosis
          Skin Manifestations Diagnosis
          Human
          Time Factors
          Retrospective Design
      ab: A retrospective analysis was conducted of eight cases of Wegener's granulomatosis (WG), who presented with cutaneous lesions. The clinical, immunopathologic and histopathologic features of the cutaneous lesions were reviewed. Antineutrophil cytoplasmic antibody (ANCA) status of the patients was established. When possible, a comparison of immunofluorescence findings of skin biopsies was made with those of renal biopsies taken at the same time. In all except one, systemic and cutaneous disease developed concurrently. On histopathology, leukocytoclastic vasculitis was noted in five patients and features of lupus erythematosus and pyoderma gangrenosum in one case each. Four patients showed immunoglobulin deposits in subepidermal blood vessel walls, while one patient showed granular immune deposits at dermo-epidermal junction only. Immunoglobulin G was the most common immunoreactant detected. C-ANCA/proteinase 3 (PR3)-ANCA was positive in six patients, P-ANCA/myeloperoxidase (MPO)-ANCA in one patient, while one patient did not show ANCA positivity on indirect immunofluorescence. All four renal biopsies showed pauci-immune glomerulonephritis, irrespective of the presence (n=3) or absence (n=1) of immune deposits in the skin biopsy. Skin manifestations are encountered in nearly half of the patients with WG, thus it is important to be familiar with cutaneous histopathologic as well as immunofluorescence findings in WG patients.
      pubtype: Academic Journal
      doctype:
        case study
        pictorial
        research
        tables/charts
        Journal Article
      ougenre: Article
    language: English
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