Biological and clinical significance of p75NTR expression in laryngeal squamous epithelia and laryngocarcinoma.
Conclusion: The apparent features of p75 neurotrophin receptor (p75NTR) expression indicated that p75NTR would serve as a potential stem cell marker for normal human laryngeal squamous epithelia. In human laryngeal squamous cell carcinoma (LSCC) p75NTR is differentially expressed. The abnormal expre...
| Publicado en: | Acta Oto-Laryngologica Vol. 132; no. 3; pp. 314 - 325 |
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| Autores principales: | , , , , , , |
| Formato: | pictorial research tables/charts Journal Article |
| Publicado: |
Taylor & Francis Ltd
Mar2012
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| Acceso en línea: | Ver este registro en EBSCOhost |
| fields | @attributes: recordID: 1 pdfLink: plink: https://search.ebscohost.com/login.aspx?direct=true&db=ccm&AN=104516678&site=ehost-live header: @attributes: shortDbName: ccm uiTerm: 104516678 longDbName: CINAHL Complete uiTag: AN controlInfo: bkinfo: dissinfo: jinfo: jid: 00016489 B6D jtl: Acta Oto-Laryngologica issn: 00016489 maglogo: Y pubinfo: dt: Mar2012 vid: 132 iid: 3 pid: 377 pub: Taylor & Francis Ltd place: Philadelphia, Pennsylvania artinfo: ui: 104516678 71754975 10.3109/00016489.2011.639086 104516678 ppf: 314 ppct: 11 formats: fmt: @attributes: type: P tig: atl: Biological and clinical significance of p75NTR expression in laryngeal squamous epithelia and laryngocarcinoma. aug: au: Li, Xiaoming Shen, Yupeng Di, Bin Li, Jun Geng, Jiangqiao Lu, Xiuying He, Zhanguo sug: subj: Carcinoma, Squamous Cell Diagnosis Laryngeal Diseases Diagnosis Receptors, Cell Surface Diagnostic Use Receptors, Cell Surface Blood Human Male Female Immunohistochemistry Methods Flow Cytometry Stem Cells Microbiology Tumor Markers, Biological Data Analysis Software Chi Square Test Nerve Growth Factors Spearman's Rank Correlation Coefficient Wilcoxon Signed Rank Test Adult Middle Age Aged Funding Source Adult: 19-44 years Middle Aged: 45-64 years Aged: 65+ years Male Female ab: Conclusion: The apparent features of p75 neurotrophin receptor (p75NTR) expression indicated that p75NTR would serve as a potential stem cell marker for normal human laryngeal squamous epithelia. In human laryngeal squamous cell carcinoma (LSCC) p75NTR is differentially expressed. The abnormal expression and distribution of p75NTR may indicate malignant transformation. Objective: To investigate the expression of p75NTR and its possible roles in normal laryngeal squamous epithelia and LSCC. Methods: We used immunohistochemistry methods to examine normal laryngeal epithelia, para-cancer mucosa with dysplasia, laryngeal papilloma, and LSCC specimens for the expression of p75NTR, nerve growth factor (NGF), -tyrosine kinase receptor (TrkA), p63, and Ki67. Immunocytochemistry and flow cytometry were used to examine the expression of p75NTR in Hep-2 cells. Results: The expression of p75NTR was only located in basal cells of normal laryngeal epithelia, consistent with the staining features of epithelial stem cells as evidenced by parallel staining of p63, a putative keratinocyte stem cell marker. p75NTR is differentially expressed in LSCC, although no significant relationship was found with many clinicopathologic factors, this expression and distribution may correlate to malignant transformation and tumor proliferation. Co-expression of p75NTR and CD133 was confirmed, showing the association of p75NTR-positive cells with cancer stem cells in Hep-2 cells. pubtype: Academic Journal doctype: pictorial research tables/charts Journal Article ougenre: Article language: English refInfo: holdings: @attributes: islocal: N |
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