Cover Image
QR Code

Is severe dysplasia the same lesion as carcinoma in situ? 10-Year follow-up of laryngeal precancerous lesions.

Conclusion. Our results showed that the behavior of moderate dysplasia lesions was more like that of severe dysplasia lesions, while severe dysplasia was very different from carcinoma in situ (CIS). CIS should be managed more aggressively than the other lesions. Mild dysplasia could not be viewed as...

Full description

Published in:Acta Oto-Laryngologica Vol. 132; no. 3; pp. 325 - 329
Main Authors: Zhang, Hong Kai, Liu, Hong Gang
Format: research tables/charts Journal Article
Published: Taylor & Francis Ltd Mar2012
Online Access:View this record in EBSCOhost
fields @attributes:
  recordID: 1
pdfLink:
plink: https://search.ebscohost.com/login.aspx?direct=true&db=ccm&AN=104516681&site=ehost-live
header:
  @attributes:
    shortDbName: ccm
    uiTerm: 104516681
    longDbName: CINAHL Complete
    uiTag: AN
  controlInfo:
    bkinfo:
    dissinfo:
    jinfo:
      jid:
        00016489
        B6D
      jtl: Acta Oto-Laryngologica
      issn: 00016489
      maglogo: Y
    pubinfo:
      dt: Mar2012
      vid: 132
      iid: 3
      pid: 377
      pub: Taylor & Francis Ltd
      place: Philadelphia, Pennsylvania
    artinfo:
      ui:
        104516681
        71754978
        10.3109/00016489.2011.642812
        NLM22229875
        104516681
      ppf: 325
      ppct: 4
      formats:
        fmt:
          @attributes:
            type: P
      tig:
        atl: Is severe dysplasia the same lesion as carcinoma in situ? 10-Year follow-up of laryngeal precancerous lesions.
      aug:
        au:
          Zhang, Hong Kai
          Liu, Hong Gang
      sug:
        subj:
          Laryngeal Neoplasms Pathology
          Precancerous Conditions
          Carcinoma in Situ Pathology
          Disease Progression
          Human
          Funding Source
          Retrospective Design
          Kaplan-Meier Estimator
          Log-Rank Test
          Chi Square Test
          Prospective Studies
          Male
          Female
          Middle Age
          Adult
          Aged
          Aged, 80 and Over
          Descriptive Statistics
          Middle Aged: 45-64 years
          Adult: 19-44 years
          Aged: 65+ years
          Aged, 80 & over
          Male
          Female
      ab: Conclusion. Our results showed that the behavior of moderate dysplasia lesions was more like that of severe dysplasia lesions, while severe dysplasia was very different from carcinoma in situ (CIS). CIS should be managed more aggressively than the other lesions. Mild dysplasia could not be viewed as a precancerous lesion of the larynx. Objective: This study aimed to identify the possibilities of the precancerous lesions of larynx (including mild dysplasia, moderate dysplasia, severe dysplasia, and CIS) progressing to invasive carcinomas and to highlight the importance of adequate management and follow-up strategies for these patients. Methods: A retrospective study of patients who had these preinvasive lesions in the larynx over a 10-year period was performed. Results: These patients were followed for a minimum period of 2 years from the initial diagnosis. In all, 86 patients were identified the cohort. Of these, 17 (19.8%) patients developed carcinoma: 0 of 22 with mild dysplasia, 5 of 25 (20%) with moderate dysplasia, 2 of 14 (15%) with severe dysplasia, and 10 of 25 (40%) patients with CIS progressed to invasive cancers ( p == 0.001). Over 50% of cases progressed 3 years after the original biopsy. Only 1 of 86 (1%) died of the disease.
      pubtype: Academic Journal
      doctype:
        research
        tables/charts
        Journal Article
      ougenre: Article
    language: English
    refInfo:
    holdings:
      @attributes:
        islocal: N