The healing effect of Teucrium polium in acetic acid-induced ulcerative colitis in the dog as an animal model.
BACKGROUND Inflammatory bowel diseases (IBD), which include ulcerative colitis (UC) and Crohn's disease (CD), are debilitating and chronic disorders with unpredictable courses and complicated treatment measures. Therefore, an efficient treatment protocol seems necessary as therapeutic prophylaxis fo...
| Publicado en: | Middle East Journal of Digestive Diseases Vol. 4; no. 1; pp. 40 - 48 |
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| Autores principales: | , , , , , , , |
| Formato: | pictorial research tables/charts Journal Article |
| Publicado: |
Iranian Association of Gastroenterology & Hepatology
Jan2012
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| Acceso en línea: | Ver este registro en EBSCOhost |
| fields | @attributes: recordID: 1 pdfLink: plink: https://search.ebscohost.com/login.aspx?direct=true&db=ccm&AN=104517348&site=ehost-live header: @attributes: shortDbName: ccm uiTerm: 104517348 longDbName: CINAHL Complete uiTag: AN controlInfo: bkinfo: dissinfo: jinfo: jid: 20085230 BG4K jtl: Middle East Journal of Digestive Diseases issn: 20085230 maglogo: N pubinfo: dt: Jan2012 vid: 4 iid: 1 pid: 70725 pub: Iranian Association of Gastroenterology & Hepatology artinfo: ui: 104517348 104517348 2011452626 NLM24829634 104517348 ppf: 40 ppct: 8 formats: fmt: @attributes: type: P tig: atl: The healing effect of Teucrium polium in acetic acid-induced ulcerative colitis in the dog as an animal model. aug: au: Mehrabani, Davood Bahrami, Faranak Hosseini, Seyed Vahid Ashraf, Mohammad Javad Tanideh, Nader Rezaianzadeh, Abbas Amini, Masoud Amini, Afshin affil: Stem Cell and Transgenic Technology Research Center, Shiraz University of Medical Sciences, Shiraz, Iran sug: subj: Acetic Acid Adverse Effects Colitis, Ulcerative Chemically Induced Plant Extracts Administration and Dosage Animal Studies Biopsy Data Analysis Software Dogs Iran Plant Extracts Therapeutic Use ab: BACKGROUND Inflammatory bowel diseases (IBD), which include ulcerative colitis (UC) and Crohn's disease (CD), are debilitating and chronic disorders with unpredictable courses and complicated treatment measures. Therefore, an efficient treatment protocol seems necessary as therapeutic prophylaxis for these disorders.This study aims to determine the healing effect of Teucrium polium(T. polium) in acetic acid-induced UC in an experimental dog model. METHODS From September to December 2010, eight male (20-25 kg) crossbred dogs were used for induction of UC by 6% acetic acid, transrectally. After one week, three biopsies (10, 20 and 30 cm proximal to the anal verge) were taken from the colon of each animal for histological studies. In the presence of UC, 400 mg/kg/day of T. polium extract was administered orally and transrectally (via enema) for 30 days in six of the dogs. The remaining two dogs were used as controls and did not receive T. polium. Multiple biopsies were taken 7, 14, and 30 days after discontinuation of T. polium in the same manner as before treatment. RESULTS After administration of acetic acid, we noted the presence of multiple ulcers, diffuse inflammation, PMN infiltration in the lamina propria, glandular destruction and goblet cell depletion. Treatment with T. polium restored the colonic architecture with an increased number of healthy cells and a reduction in inflammatory cells. Damage of the surface epithelial cells and mucosal layer of the lumen were reversed,which lead to faster ulcer healing. CONCLUSION T. polium may be a treatment choice for UC and can broaden the current therapy options for UC. pubtype: Academic Journal doctype: pictorial research tables/charts Journal Article ougenre: Article language: English refInfo: holdings: @attributes: islocal: N |
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