Application of CT perfusion imaging to the histological differentiation of adrenal gland tumors.
Background: CT perfusion imaging has been used in diagnosis and classification of tumors widely and in assess tumor angiogenesis in some organs. However, there are few reports describing CT perfusion imaging of adrenal gland tumors. Objective: This study aimed to evaluate the application of CT perfu...
| Publicado en: | European Journal of Radiology Vol. 81; no. 3; pp. 502 - 508 |
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| Autores principales: | , , , , , , , |
| Formato: | research Journal Article |
| Publicado: |
Elsevier B.V.
Mar2012
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| Acceso en línea: | Ver este registro en EBSCOhost |
| fields | @attributes: recordID: 1 pdfLink: plink: https://search.ebscohost.com/login.aspx?direct=true&db=ccm&AN=104517938&site=ehost-live header: @attributes: shortDbName: ccm uiTerm: 104517938 longDbName: CINAHL Complete uiTag: AN controlInfo: bkinfo: dissinfo: jinfo: jid: 0720048X 3S7 jtl: European Journal of Radiology issn: 0720048X maglogo: N pubinfo: dt: Mar2012 vid: 81 iid: 3 pid: 1004 pub: Elsevier B.V. artinfo: ui: 104517938 NLM21306850 2011455361 10.1016/j.ejrad.2010.12.072 NLM21306850 104517938 ppf: 502 ppct: 6 formats: tig: atl: Application of CT perfusion imaging to the histological differentiation of adrenal gland tumors. aug: au: Qin HY Sun HR Li YJ Shen BZ Qin, Hai-yan Sun, Hao-ran Li, Ya-jun Shen, Bao-zhong affil: Department of Imaging, The Fourth Affiliated Hospital, Harbin Medical University, Harbin 150001, China sug: subj: Adenoma Radiography Adrenal Gland Neoplasms Radiography Neovascularization, Pathologic Radiography Tomography, X-Ray Computed Methods Adenoma Pathology Adrenal Gland Neoplasms Pathology Algorithms Blood Volume Contrast Media Diagnostic Use Diagnosis, Differential Female Human Contrast Media Logistic Regression Male Middle Age Neovascularization, Pathologic Pathology ROC Curve Radiographic Image Interpretation, Computer-Assisted Sensitivity and Specificity Software Middle Aged: 45-64 years Female Male ab: Background: CT perfusion imaging has been used in diagnosis and classification of tumors widely and in assess tumor angiogenesis in some organs. However, there are few reports describing CT perfusion imaging of adrenal gland tumors. Objective: This study aimed to evaluate the application of CT perfusion imaging in analysis of angiogenesis in adrenal tumors and in diagnosis of adrenal tumors. Patients and Methods: Forty four patients with adrenal gland tumors (26 with adenomas and 18 with nonadenomas) were enrolled in this study. CT scan of adrenal glands was performed with the perfusion of non-ionic contrast medium Ultravist. The obtained images were processed with deconvolution algorithms-based perfusion software and then perfusion parameter maps and values (blood flow, blood volume, mean transit time, and permeability surface-area production) were generated and analyzed respectively. Results: Univariate multivariate logistic regression indicated that blood volume (OR: 1.261, 95% CI: 1.056, 1.505, P=0.010) was associated with the likelihood of adrenal adenoma. Receiver operating characteristic analysis showed that the blood volume value of ≥9.325 ml min(-1) 100 g(-1) predicted adrenal adenoma with sensitivity of 76.9% and specificity of 73.2%. In addition, permeability surface-area production in adenoma was higher than in non-adenoma (27.11±15.45 vs. 16.76±14.44 ml min(-1) 100 g(-1), P<0.05). The other parameters had no clear prognostic significance. Conclusions: CT perfusion imaging can quantitatively distinguish adrenal gland tumors with different histological characteristics. Especially, blood volume can be used in differentiating adrenal adenomas from nonadenomas. pubtype: Academic Journal doctype: research Journal Article ougenre: Article language: English refInfo: holdings: @attributes: islocal: N |
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