Effect of long-acting beta-agonists on the frequency of COPD exacerbations: a meta-analysis.
Summary What is Known and Objective: Inhaled long-acting beta-agonists have been licensed for the treatment of chronic obstructive pulmonary disease (COPD) since the late 1990s, and they improve lung function and symptoms of dyspnoea. However, the evidence that long-acting beta-agonists alone can re...
| Publicado en: | Journal of Clinical Pharmacy & Therapeutics Vol. 37; no. 2; pp. 204 - 212 |
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| Autores principales: | , , , |
| Formato: | research systematic review tables/charts Journal Article |
| Publicado: |
Wiley-Blackwell
Apr2012
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| Acceso en línea: | Ver este registro en EBSCOhost |
| fields | @attributes: recordID: 1 pdfLink: plink: https://search.ebscohost.com/login.aspx?direct=true&db=ccm&AN=104527765&site=ehost-live header: @attributes: shortDbName: ccm uiTerm: 104527765 longDbName: CINAHL Complete uiTag: AN controlInfo: bkinfo: dissinfo: jinfo: jid: 02694727 EV4 jtl: Journal of Clinical Pharmacy & Therapeutics issn: 02694727 maglogo: Y pubinfo: dt: Apr2012 vid: 37 iid: 2 pid: 480 pub: Wiley-Blackwell place: Malden, Massachusetts artinfo: ui: 104527765 72417262 10.1111/j.1365-2710.2011.01285.x NLM21740451 104527765 ppf: 204 ppct: 8 formats: fmt: @attributes: type: P tig: atl: Effect of long-acting beta-agonists on the frequency of COPD exacerbations: a meta-analysis. aug: au: Wang, J. Nie, B. Xiong, W. Xu, Y. affil: Department of Respiratory Medicine, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China sug: subj: Pulmonary Disease, Chronic Obstructive Drug Therapy Adrenergic beta-Agonists Therapeutic Use Disease Exacerbation Adrenergic beta-Agonists Administration and Dosage Meta Analysis Human Odds Ratio Confidence Intervals Randomized Controlled Trials Pulmonary Disease, Chronic Obstructive Physiopathology Administration, Inhalation Male Female Descriptive Statistics Middle Age Aged Delayed-Action Preparations Salmeterol Administration and Dosage Salmeterol Therapeutic Use Bronchodilator Agents Administration and Dosage Bronchodilator Agents Therapeutic Use Data Analysis Software Systematic Review Medline Embase CINAHL Database Cochrane Library Middle Aged: 45-64 years Aged: 65+ years Male Female ab: Summary What is Known and Objective: Inhaled long-acting beta-agonists have been licensed for the treatment of chronic obstructive pulmonary disease (COPD) since the late 1990s, and they improve lung function and symptoms of dyspnoea. However, the evidence that long-acting beta-agonists alone can reduce the rate of COPD exacerbations is not conclusive. This meta-analysis was performed to evaluate their effect on the frequency of exacerbations. Methods: MEDLINE, EMBASE, CINAHL and the Cochrane trials database were searched for the review. Randomized controlled trials of greater than or equal to 24 weeks' treatment duration comparing long-acting beta-agonists (LABAs) with placebo were reviewed. Studies were pooled to yield odds ratios (ORs) with 95% confidence intervals (CIs). Results and Discussion: Seventeen randomized controlled trials (11871 randomized subjects) met the inclusion criteria and were selected for analysis. Salmeterol, formoterol and indacaterol significantly reduced COPD exacerbations compared with placebo. Salmeterol significantly reduced COPD exacerbations with both study arms exposed or not exposed to inhaled corticosteroids (ICS). The summary ORs were 0·79 (95% CI: 0·67-0·92; P < 0·01) and 0·80 (95% CI: 0·65-0·99; P = 0·04), respectively. However, when both arms were not exposed to ICS, there was no significant reduction in exacerbations with formoterol compared with placebo. The 'summary OR was 0·93 (95% CI: 0·75-1·15; P = 0·50). What is New and Conclusion: Long-acting beta-agonists reduce the frequency of COPD exacerbations. Salmeterol, formoterol and indacaterol significantly reduced COPD exacerbations compared with placebo. Salmeterol but not formoterol decreased exacerbations significantly in the absence of ICS. pubtype: Academic Journal doctype: meta analysis research systematic review tables/charts Journal Article ougenre: Article language: English refInfo: holdings: @attributes: islocal: N |
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