Normal variation in behavioral adjustment relates to regional differences in cortical thickness in children.
Neuroanatomical correlates of developmental psychopathology such as attention deficit hyperactivity and conduct disorder have been identified. The majority of studies point to lesser gray matter in psychopathology, often involving prefrontal cortices. The goal of this study was to test whether simil...
| Publicado en: | European Child & Adolescent Psychiatry Vol. 21; no. 3; pp. 133 - 141 |
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| Autores principales: | , , , , |
| Formato: | diagnostic images research tables/charts Journal Article |
| Publicado: |
Springer Nature
Mar2012
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| Acceso en línea: | Ver este registro en EBSCOhost |
| fields | @attributes: recordID: 1 pdfLink: plink: https://search.ebscohost.com/login.aspx?direct=true&db=ccm&AN=104528615&site=ehost-live header: @attributes: shortDbName: ccm uiTerm: 104528615 longDbName: CINAHL Complete uiTag: AN controlInfo: bkinfo: dissinfo: jinfo: jid: 10188827 EJ3 jtl: European Child & Adolescent Psychiatry issn: 10188827 maglogo: N pubinfo: dt: Mar2012 vid: 21 iid: 3 pid: 237 pub: Springer Nature place: New York, New York artinfo: ui: 104528615 72898564 10.1007/s00787-012-0241-5 104528615 ppf: 133 ppct: 8 formats: fmt: @attributes: type: P tig: atl: Normal variation in behavioral adjustment relates to regional differences in cortical thickness in children. aug: au: Walhovd, Kristine Tamnes, Christian Østby, Ylva Due-Tønnessen, Paulina Fjell, Anders affil: Department of Psychology, Center for the Study of Human Cognition (CSHC), University of Oslo, Blindern 0317 Oslo Norway sug: subj: Adaptation, Psychological In Infancy and Childhood Child Behavior Disorders Physiopathology Brain Physiopathology Human Child Adolescence Interviews Male Female Magnetic Resonance Imaging Adult Descriptive Statistics Cross Sectional Studies Funding Source Child: 6-12 years Adolescent: 13-18 years Adult: 19-44 years Male Female ab: Neuroanatomical correlates of developmental psychopathology such as attention deficit hyperactivity and conduct disorder have been identified. The majority of studies point to lesser gray matter in psychopathology, often involving prefrontal cortices. The goal of this study was to test whether similar neural correlates exist for behavioral variance in healthy children and adolescents. A large sample ( n = 106) aged 8-19 years underwent MR scanning and their parents completed the Strength and Difficulties Questionnaire. The relationships between cortical thickness and conduct problems and hyperactivity/inattention scale scores were investigated throughout the cerebrum. No associations were found between normal variance in hyperactivity/inattention and cortical thickness. Normal variance in conduct problems was associated with thinner left hemisphere prefrontal and supramarginal cortices. Relationships between conduct problems and cortical thickness interacted with age, with the greatest differences in cortical thickness seen in the younger children. These interactions were observed in the anterior cingulate, orbitofrontal, middle and superior frontal, as well as lateral and medial temporal cortices. In conclusion, the results indicate neurobiological continuity between symptoms of conduct problems within the normal range, and conduct disorder. Relationships of thinner cortices and conduct problems were primarily seen in younger children, and appeared to decrease with age, indicative of different maturational trajectories in the groups. The long-term consequences are unknown, and the results point to a need for longitudinal studies of developmental trajectories of neuroanatomical foundations of behavioral adjustment. pubtype: Academic Journal doctype: diagnostic images research tables/charts Journal Article ougenre: Article language: English refInfo: holdings: @attributes: islocal: N |
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