Laboratory animal models for brucellosis research.
Brucellosis is a chronic infectious disease caused by Brucella spp., a gram-negative facultative intracellular pathogen that affects humans and animals, leading to significant impact on public health and animal industry. Human brucellosis is considered the most prevalent bacterial zoonosis in the wo...
| Publicado en: | Journal of Biomedicine & Biotechnology pp. 518323 - 518324 |
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| Autores principales: | , , , , |
| Formato: | Journal Article |
| Publicado: |
Wiley-Blackwell
2011
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| Acceso en línea: | Ver este registro en EBSCOhost |
| fields | @attributes: recordID: 1 pdfLink: plink: https://search.ebscohost.com/login.aspx?direct=true&db=ccm&AN=104531575&site=ehost-live header: @attributes: shortDbName: ccm uiTerm: 104531575 longDbName: CINAHL Complete uiTag: AN controlInfo: bkinfo: dissinfo: jinfo: jid: 11107243 137K jtl: Journal of Biomedicine & Biotechnology issn: 11107243 maglogo: N pubinfo: dt: 2011 pid: 480 pub: Wiley-Blackwell place: Malden, Massachusetts artinfo: ui: 104531575 2011456986 NLM21403904 PMC3043301 104531575 ppf: 518323 ppct: 1 formats: fmt: @attributes: type: P tig: atl: Laboratory animal models for brucellosis research. aug: au: Silva, Teane M A Costa, Erica A Paixao, Tatiane A Tsolis, Renée M Santos, Renato L affil: Departamento de Clínica e Cirurgia Veterinária, Escola de Veterinária, Universidade Federal de Minas Gerais, 31270-901 Belo Horizonte, MG, Brazil. sug: subj: Brucellosis Pathology Brucellosis Prevention and Control Brucellosis Therapy Models, Biological Animals Gram-Negative Aerobic Bacteria Immunology Gram-Negative Aerobic Bacteria Bacterial Vaccines Immunology Bacterial Vaccines Therapeutic Use Guinea Pigs Primates Mice Rats ab: Brucellosis is a chronic infectious disease caused by Brucella spp., a gram-negative facultative intracellular pathogen that affects humans and animals, leading to significant impact on public health and animal industry. Human brucellosis is considered the most prevalent bacterial zoonosis in the world and is characterized by fever, weight loss, depression, hepato/splenomegaly, osteoarticular, and genital infections. Relevant aspects of Brucella pathogenesis have been intensively investigated in culture cells and animal models. The mouse is the animal model more commonly used to study chronic infection caused by Brucella. This model is most frequently used to investigate specific pathogenic factors of Brucella spp., to characterize the host immune response, and to evaluate therapeutics and vaccines. Other animal species have been used as models for brucellosis including rats, guinea pigs, and monkeys. This paper discusses the murine and other laboratory animal models for human and animal brucellosis. pubtype: Academic Journal doctype: Journal Article ougenre: Article language: English refInfo: holdings: @attributes: islocal: N |
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