MicroRNA gene dosage alterations and drug response in lung cancer.
Chemotherapy resistance is a key contributor to the dismal prognoses for lung cancer patients. While the majority of studies have focused on sequence mutations and expression changes in protein-coding genes, recent reports have suggested that microRNA (miRNA) expression changes also play an influent...
| Publicado en: | Journal of Biomedicine & Biotechnology pp. 474632 - 474633 |
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| Autores principales: | , , , , , , |
| Formato: | research Journal Article |
| Publicado: |
Wiley-Blackwell
2011
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| Acceso en línea: | Ver este registro en EBSCOhost |
| fields | @attributes: recordID: 1 pdfLink: plink: https://search.ebscohost.com/login.aspx?direct=true&db=ccm&AN=104531589&site=ehost-live header: @attributes: shortDbName: ccm uiTerm: 104531589 longDbName: CINAHL Complete uiTag: AN controlInfo: bkinfo: dissinfo: jinfo: jid: 11107243 137K jtl: Journal of Biomedicine & Biotechnology issn: 11107243 maglogo: N pubinfo: dt: 2011 pid: 480 pub: Wiley-Blackwell place: Malden, Massachusetts artinfo: ui: 104531589 104531589 2011457000 NLM21541180 PMC3085440 104531589 ppf: 474632 ppct: 1 formats: fmt: @attributes: type: P tig: atl: MicroRNA gene dosage alterations and drug response in lung cancer. aug: au: Enfield, Katey S S Stewart, Greg L Pikor, Larissa A Alvarez, Carlos E Lam, Stephen Lam, Wan L Chari, Raj affil: British Columbia Cancer Research Centre, Vancouver, BC, Canada. kenfield@bccrc.ca sug: subj: Genotype Lung Neoplasms Drug Therapy Lung Neoplasms RNA Cells Gene Expression Profiling Genes Genome ab: Chemotherapy resistance is a key contributor to the dismal prognoses for lung cancer patients. While the majority of studies have focused on sequence mutations and expression changes in protein-coding genes, recent reports have suggested that microRNA (miRNA) expression changes also play an influential role in chemotherapy response. However, the role of genetic alterations at miRNA loci in the context of chemotherapy response has yet to be investigated. In this study, we demonstrate the application of an integrative, multidimensional approach in order to identify miRNAs that are associated with chemotherapeutic resistance and sensitivity utilizing publicly available drug response, miRNA loci copy number, miRNA expression, and mRNA expression data from independent resources. By instigating a logical stepwise strategy, we have identified specific miRNAs that are associated with resistance to several chemotherapeutic agents and provide a proof of principle demonstration of how these various databases may be exploited to derive relevant pharmacogenomic results. pubtype: Academic Journal doctype: research Journal Article ougenre: Article language: English refInfo: holdings: @attributes: islocal: N |
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