Molecular imaging, pharmacokinetics, and dosimetry of In-AMBA in human prostate tumor-bearing mice.
Molecular imaging with promise of personalized medicine can provide patient-specific information noninvasively, thus enabling treatment to be tailored to the specific biological attributes of both the disease and the patient. This study was to investigate the characterization of DO3A-CH(2)CO-G-4-ami...
| Publicado en: | Journal of Biomedicine & Biotechnology pp. 101497 - 101498 |
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| Autores principales: | , , , , , , , , , , |
| Formato: | research Journal Article |
| Publicado: |
Wiley-Blackwell
2011
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| Acceso en línea: | Ver este registro en EBSCOhost |
| fields | @attributes: recordID: 1 pdfLink: plink: https://search.ebscohost.com/login.aspx?direct=true&db=ccm&AN=104531630&site=ehost-live header: @attributes: shortDbName: ccm uiTerm: 104531630 longDbName: CINAHL Complete uiTag: AN controlInfo: bkinfo: dissinfo: jinfo: jid: 11107243 137K jtl: Journal of Biomedicine & Biotechnology issn: 11107243 maglogo: N pubinfo: dt: 2011 pid: 480 pub: Wiley-Blackwell place: Malden, Massachusetts artinfo: ui: 104531630 104531630 2011457041 NLM21660132 PMC3110286 104531630 ppf: 101497 ppct: 1 formats: fmt: @attributes: type: P tig: atl: Molecular imaging, pharmacokinetics, and dosimetry of In-AMBA in human prostate tumor-bearing mice. aug: au: Ho, Chung-Li Liu, I-Hsiang Wu, Yu-Hsien Chen, Liang-Cheng Chen, Chun-Lin Lee, Wan-Chi Chuang, Cheng-Hui Lee, Te-Wei Lin, Wuu-Jyh Shen, Lie-Hang Chang, Chih-Hsien affil: Isotope Application Division, Institute of Nuclear Energy Research, Taoyuan 32546, Taiwan. sug: subj: Radioisotopes Diagnostic Use Radioisotopes Pharmacokinetics Molecular Imaging Methods Oligopeptides Diagnostic Use Oligopeptides Pharmacokinetics Prostatic Neoplasms Radiography Animals Cells Epithelial Cells Time Isotopes Male Mice Radiometry Methods Radiopharmaceuticals Diagnostic Use Radiopharmaceuticals Pharmacokinetics Receptors, Cell Surface Metabolism Tomography, Emission-Computed, Single-Photon Methods Xenografts Male ab: Molecular imaging with promise of personalized medicine can provide patient-specific information noninvasively, thus enabling treatment to be tailored to the specific biological attributes of both the disease and the patient. This study was to investigate the characterization of DO3A-CH(2)CO-G-4-aminobenzoyl-Q-W-A-V-G-H-L-M-NH(2) (AMBA) in vitro, MicroSPECT/CT imaging, and biological activities of (111)In-AMBA in PC-3 prostate tumor-bearing SCID mice. The uptake of (111)In-AMBA reached highest with 3.87 ± 0.65% ID/g at 8 h. MicroSPECT/CT imaging studies suggested that the uptake of (111)In-AMBA was clearly visualized between 8 and 48 h postinjection. The distribution half-life (t(1/2[alpha])) and the elimination half-life (t(1/2[beta])) of (111)In-AMBA in mice were 1.53 h and 30.7 h, respectively. The C(max) and AUC of (111)In-AMBA were 7.57% ID/g and 66.39 h % ID/g, respectively. The effective dose appeared to be 0.11 mSv/MBq(-1). We demonstrated a good uptake of (111)In-AMBA in the GRPR-overexpressed PC-3 tumor-bearing SCID mice. (111)In-AMBA is a safe, potential molecular image-guided diagnostic agent for human GRPR-positive tumors, ranging from simple and straightforward biodistribution studies to improve the efficacy of combined modality anticancer therapy. pubtype: Academic Journal doctype: research Journal Article ougenre: Article language: English refInfo: holdings: @attributes: islocal: N |
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