Early detection of tumor response by FLT/microPET Imaging in a C26 murine colon carcinoma solid tumor animal model.
Fluorine-18 fluorodeoxyglucose ((18)F-FDG) positron emission tomography (PET) imaging demonstrated the change of glucose consumption of tumor cells, but problems with specificity and difficulties in early detection of tumor response to chemotherapy have led to the development of new PET tracers. Flu...
| Publicado en: | Journal of Biomedicine & Biotechnology pp. 535902 - 535903 |
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| Autores principales: | , , , , , , , |
| Formato: | research Journal Article |
| Publicado: |
Wiley-Blackwell
2011
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| Acceso en línea: | Ver este registro en EBSCOhost |
| fields | @attributes: recordID: 1 pdfLink: plink: https://search.ebscohost.com/login.aspx?direct=true&db=ccm&AN=104531699&site=ehost-live header: @attributes: shortDbName: ccm uiTerm: 104531699 longDbName: CINAHL Complete uiTag: AN controlInfo: bkinfo: dissinfo: jinfo: jid: 11107243 137K jtl: Journal of Biomedicine & Biotechnology issn: 11107243 maglogo: N pubinfo: dt: 2011 pid: 480 pub: Wiley-Blackwell place: Malden, Massachusetts artinfo: ui: 104531699 104531699 2011457110 NLM21869861 PMC3157890 104531699 ppf: 535902 ppct: 1 formats: fmt: @attributes: type: P tig: atl: Early detection of tumor response by FLT/microPET Imaging in a C26 murine colon carcinoma solid tumor animal model. aug: au: Lee, Wan-Chi Chang, Chih-Hsien Ho, Chung-Li Chen, Liang-Cheng Wu, Yu-Hsien Chen, Jenn-Tzong Wang, Ying-Ling Lee, Te-Wei affil: Isotope Application Division, Institute of Nuclear Energy Research, Taoyuan 32546, Taiwan. sug: subj: Colonic Neoplasms Drug Therapy Colonic Neoplasms Radiography Deoxyribonucleosides Diagnostic Use Tomography, Emission-Computed Methods Radiopharmaceuticals Diagnostic Use Animals Antibiotics, Antineoplastic Administration and Dosage Colonic Neoplasms Metabolism Deoxyribonucleosides Pharmacokinetics Doxorubicin Administration and Dosage Fludeoxyglucose F 18 Diagnostic Use Fludeoxyglucose F 18 Pharmacokinetics Male Mice Radiopharmaceuticals Pharmacokinetics Male ab: Fluorine-18 fluorodeoxyglucose ((18)F-FDG) positron emission tomography (PET) imaging demonstrated the change of glucose consumption of tumor cells, but problems with specificity and difficulties in early detection of tumor response to chemotherapy have led to the development of new PET tracers. Fluorine-18-fluorothymidine ((18)F-FLT) images cellular proliferation by entering the salvage pathway of DNA synthesis. In this study, we evaluate the early response of colon carcinoma to the chemotherapeutic drug, lipo-Dox, in C26 murine colorectal carcinoma-bearing mice by (18)F-FDG and (18)F-FLT. The male BALB/c mice were bilaterally inoculated with 1 x 10(5) and 1 x 10(6) C26 tumor cells per flank. Mice were intravenously treated with 10 mg/kg lipo-Dox at day 8 after (18)F-FDG and (18)F-FLT imaging. The biodistribution of (18)F-FDG and (18)F-FLT were followed by the microPET imaging at day 9. For the quantitative measurement of microPET imaging at day 9, (18)F-FLT was superior to (18)F-FDG for early detection of tumor response to Lipo-DOX at various tumor sizes (P < 0.05). The data of biodistribution showed similar results with those from the quantification of SUV (standard uptake value) by microPET imaging. The study indicates that (18)F-FLT/microPET is a useful imaging modality for early detection of chemotherapy in the colorectal mouse model. pubtype: Academic Journal doctype: research Journal Article ougenre: Article language: English refInfo: holdings: @attributes: islocal: N |
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