Spectrum of neurodevelopmental disabilities in children with cerebellar malformations.
AIM: Advances in perinatal care and neuroimaging techniques have increased the detection of cerebellar malformations (CBMs) in the fetus and young infant. As a result, this has necessitated a greater understanding of the neurodevelopmental consequences of CBMs on child development. The aim of this s...
| Publicado en: | Developmental Medicine & Child Neurology Vol. 53; no. 5; pp. 409 - 417 |
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| Autores principales: | , , , , , , , |
| Formato: | research Journal Article |
| Publicado: |
Wiley-Blackwell
May2011
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| Acceso en línea: | Ver este registro en EBSCOhost |
| fields | @attributes: recordID: 1 pdfLink: plink: https://search.ebscohost.com/login.aspx?direct=true&db=ccm&AN=104531757&site=ehost-live header: @attributes: shortDbName: ccm uiTerm: 104531757 longDbName: CINAHL Complete uiTag: AN controlInfo: bkinfo: dissinfo: jinfo: jid: 00121622 1VN jtl: Developmental Medicine & Child Neurology issn: 00121622 maglogo: Y pubinfo: dt: May2011 vid: 53 iid: 5 pid: 480 pub: Wiley-Blackwell place: Malden, Massachusetts artinfo: ui: 104531757 2011481191 10.1111/j.1469-8749.2011.03929.x NLM21418200 104531757 ppf: 409 ppct: 8 formats: tig: atl: Spectrum of neurodevelopmental disabilities in children with cerebellar malformations. aug: au: Bolduc ME Du Plessis AJ Sullivan N Khwaja OS Zhang X Barnes K Robertson RL Limperopoulos C affil: School of Physical and Occupational Therapy, McGill University, Montreal, Quebec, Canada. sug: subj: Cerebellar Diseases Complications Cerebellar Diseases Pathology Cerebellum Abnormalities Developmental Disabilities Etiology Cerebellar Diseases Psychosocial Factors Child, Preschool Cognition Disorders Diagnosis Cognition Disorders Etiology Cross Sectional Studies Developmental Disabilities Diagnosis Female Prospective Studies Infant Magnetic Resonance Imaging Male Neurologic Examination Predictive Value of Tests Quality of Life Regression Social Behavior Scales Child Behavior Checklist Checklists Clinical Assessment Tools Human Child, Preschool: 2-5 years Infant: 1-23 months Female Male ab: AIM: Advances in perinatal care and neuroimaging techniques have increased the detection of cerebellar malformations (CBMs) in the fetus and young infant. As a result, this has necessitated a greater understanding of the neurodevelopmental consequences of CBMs on child development. The aim of this study was to delineate the impact of CBMs on long-term neurodevelopmental outcomes. METHOD: We conducted a cross-sectional study and systematically identified children with CBMs born between December 2000 and December 2006. We then performed follow-up magnetic resonance imaging studies, neurologic examination, and standardized neurodevelopmental outcome testing (Mullen Scales of Early Learning, Vineland Adaptive Behavior Scale, Child Behavior Checklist, Modified Checklist for Autism in Toddlers, and the Pediatric Quality of Life Inventory). RESULTS: Our sample comprised 49 children (29 males, 20 females; mean age, 28.4 mo, SD 16.4) with a CBM. Infants with evidence of acquired fetal or neonatal brain injury, intracranial birth trauma, inherited metabolic disease, or major pre- or postnatal cerebral ischemia were excluded. Our findings highlight that children with CBMs experience a high prevalence of neurologic, developmental, and functional disabilities including motor, cognitive, language, and social-behavioral deficits, as well as poor quality of life. The associated supratentorial anomalies, chromosomal findings, and malformations affecting the cerebellar vermis were significant independent predictors of neurodevelopmental disabilities in young children with CBMs. The associated supratentorial anomalies and chromosomal findings were also predictive of global developmental delay (p=0.01), cognitive impairment (p=0.03), gross and fine motor delay (p=0.02 and p=0.01 respectively), and positive screening for autism spectrum disorder (p=0.01). Additionally, malformations affecting the cerebellar vermis were significant independent predictors of expressive language (p=0.04) and gross motor delays (p=0.02). INTERPRETATION: Developmental surveillance and early intervention programs should be an integral part of the long-term follow-up of survivors of CBM. pubtype: Academic Journal doctype: research Journal Article ougenre: Article language: English refInfo: holdings: @attributes: islocal: N |
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