Intestinal methane production in obese individuals is associated with a higher body mass index.
Background: Obesity is an epidemic that affects 1 in 3 individuals in the United States, and recent evidence suggests that enteric microbiota may play a significant role in the development of obesity. This study evaluated the association between methanogenic archaea and obesity in human subjects. Me...
| Published in: | Gastroenterology & Hepatology Vol. 8; no. 1; pp. 22 - 29 |
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| Main Authors: | , , , , , , , , , |
| Format: | research tables/charts Journal Article |
| Published: |
Gastro-Hep Communications, Inc
Jan2012
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| Online Access: | View this record in EBSCOhost |
| fields | @attributes: recordID: 1 pdfLink: plink: https://search.ebscohost.com/login.aspx?direct=true&db=ccm&AN=104534209&site=ehost-live header: @attributes: shortDbName: ccm uiTerm: 104534209 longDbName: CINAHL Complete uiTag: AN controlInfo: bkinfo: dissinfo: jinfo: jid: 15547914 6N5B jtl: Gastroenterology & Hepatology issn: 15547914 maglogo: N pubinfo: dt: Jan2012 vid: 8 iid: 1 pid: 72163 pub: Gastro-Hep Communications, Inc place: New York, New York artinfo: ui: 104534209 104534209 2011489551 NLM22347829 104534209 ppf: 22 ppct: 7 formats: fmt: @attributes: type: P tig: atl: Intestinal methane production in obese individuals is associated with a higher body mass index. aug: au: Basseri, Robert J Basseri, Benjamin Pimentel, Mark Chong, Kelly Youdim, Adrienne Low, Kimberly Hwang, Laura Soffer, Edy Chang, Christopher Mathur, Ruchi affil: GI Mobility Program, Cedars-Sinai Medical Center, Los Angeles, CA sug: subj: Body Mass Index Intestines Methane Obesity Academic Medical Centers Adult California Equipment and Supplies Female Human Male Middle Age Multivariate Analysis Prospective Studies Questionnaires Symptoms Visual Analog Scaling Adult: 19-44 years Middle Aged: 45-64 years Female Male ab: Background: Obesity is an epidemic that affects 1 in 3 individuals in the United States, and recent evidence suggests that enteric microbiota may play a significant role in the development of obesity. This study evaluated the association between methanogenic archaea and obesity in human subjects. Methods: Subjects with a body mass index (BMI) of 30 kg/m2 or higher were prospectively recruited from the weight loss program of a tertiary care medical center. Subjects who met the study's inclusion criteria were asked to complete a questionnaire that included a series of visual analogue scores for bowel symptom severities. Subjects then provided a single end-expiratory breath sample to quantitate methane levels. Bivariate and multivariate analyses were used to determine associations with BMI. Results: A total of 58 patients qualified for enrollment. Twenty percent of patients (n=12) had breath test results that were positive for methane (>3 parts per million [ppm]), with a mean breath methane concentration of 12.2±3.1 ppm. BMI was significantly higher in methane-positive subjects (45.2±2.3 kg/m2) than in methane-negative subjects (38.5±0.8 kg/m2; P=.001). Methane-positive subjects also had a greater severity of constipation than methane-negative subjects (21.3±6.4 vs 9.5±2.4; P=.043). Multiple regression analysis illustrated a significant association between BMI and methane, constipation, and antidepressant use. However, methane remained an independent predictor of elevated BMI when controlling for antidepressant use (P<.001) and when controlling for both constipation and antidepressant use (6.55 kg/m2 greater BMI; P=.003). Conclusion: This is the first human study to demonstrate that a higher concentration of methane detected by breath testing is a predictor of significantly greater obesity in overweight subjects. pubtype: Academic Journal doctype: research tables/charts Journal Article ougenre: Article language: English refInfo: holdings: @attributes: islocal: N |
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