Quantitative assessment of tumour associated neovascularisation in patients with liver cirrhosis and hepatocellular carcinoma: role of dynamic-CT perfusion imaging.
Objective: To determine the value of perfusion computed tomography (CT-p) in the quantitative assessment of tumour-related neoangiogenesis processes in patients with hepatocellular carcinoma (HCC).Materials and Methods: Fifty-two biopsy proven HCC lesions were examined with dynamic CT investigations...
| Publicado en: | European Radiology Vol. 22; no. 4; pp. 803 - 812 |
|---|---|
| Autores principales: | , , , , , , , , , |
| Formato: | research Journal Article |
| Publicado: |
Springer Nature
Apr2012
|
| Acceso en línea: | Ver este registro en EBSCOhost |
| fields | @attributes: recordID: 1 pdfLink: plink: https://search.ebscohost.com/login.aspx?direct=true&db=ccm&AN=104534368&site=ehost-live header: @attributes: shortDbName: ccm uiTerm: 104534368 longDbName: CINAHL Complete uiTag: AN controlInfo: bkinfo: dissinfo: jinfo: jid: 09387994 NPH jtl: European Radiology issn: 09387994 maglogo: N pubinfo: dt: Apr2012 vid: 22 iid: 4 pid: 237 pub: Springer Nature place: New York, New York artinfo: ui: 104534368 NLM22086560 2011490208 10.1007/s00330-011-2307-z NLM22086560 104534368 ppf: 803 ppct: 9 formats: fmt: @attributes: type: P tig: atl: Quantitative assessment of tumour associated neovascularisation in patients with liver cirrhosis and hepatocellular carcinoma: role of dynamic-CT perfusion imaging. aug: au: Ippolito D Capraro C Casiraghi A Cestari C Sironi S Ippolito, Davide Capraro, Cristina Casiraghi, Alessandra Cestari, Cristina Sironi, Sandro affil: School of Medicine, University of Milano-Bicocca, Milan, Italy sug: subj: Carcinoma, Hepatocellular Radiography Liver Cirrhosis Radiography Liver Neoplasms Radiography Neovascularization, Pathologic Radiography Perfusion Imaging Methods Radiographic Image Interpretation, Computer-Assisted Methods Tomography, X-Ray Computed Methods Adult Aged Algorithms Carcinoma, Hepatocellular Complications Female Human Liver Cirrhosis Etiology Liver Neoplasms Complications Male Middle Age Neovascularization, Pathologic Complications Reproducibility of Results Sensitivity and Specificity Adult: 19-44 years Aged: 65+ years Middle Aged: 45-64 years Female Male ab: Objective: To determine the value of perfusion computed tomography (CT-p) in the quantitative assessment of tumour-related neoangiogenesis processes in patients with hepatocellular carcinoma (HCC).Materials and Methods: Fifty-two biopsy proven HCC lesions were examined with dynamic CT investigations during injection of 50 mL of contrast agent (350 mgI/mL). A dedicated perfusion software which generated a quantitative map of arterial and portal perfusion by means of a colour scale was employed. The following parameters related to the blood microcirculation and tissue perfusion were calculated: hepatic perfusion (Perf), tissue blood volume (BV), hepatic perfusion index (HPI), arterial perfusion (AP), portal perfusion (PP), and time to peak (TTP). Perfusion parameters were statistically analysed, comparing neoplastic lesions with cirrhotic parenchyma.Results: Perf, BV, HPI and AP values were higher (P < 0.001), whereas PP and TTP were lower (P < 0.001) in HCC relative to the surrounding liver. No significant correlation was found between perfusion parameters and HCC grade. Values of perfusion parameters in the cirrhotic liver of patients with and without HCC were not significantly different.Conclusions: Our results suggest that CT-p can help in non-invasive quantification of tumour blood supply, related to the formation of new arterial structures (neoangiogenesis), which are essential for tumour growth.Key Points: Perfusion computed tomography (CT) enables depiction of tumour vascular physiology. Perfusion CT is non-invasive and is now quick to perform and analyse. Quantitative measurements of hepatic perfusion provide important information about hepatocellular carcinoma (HCC). Such perfusion CT data may help in the determination of the outcome of HCC. Perfusion CT can act as an in-vivo biomarker of tumour-related angiogenesis. pubtype: Academic Journal doctype: research Journal Article ougenre: Article language: English refInfo: holdings: @attributes: islocal: N |
|---|