Prediction for steatosis in type-2 diabetes: clinico-biological markers versus 1H-MR spectroscopy.
Objectives: The SteatoTest, fatty liver index (FLI) and hepatic steatosis index (HSI) are clinico-biological scores of steatosis validated in general or selected populations. Serum adiponectin (s-adiponectin) and retinol binding protein 4 (s-RBP4) are adipokines that could predict liver steatosis. W...
| Publicado en: | European Radiology Vol. 22; no. 4; pp. 855 - 864 |
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| Autores principales: | , , , , , , , , , , , , , , , , , , , |
| Formato: | research Journal Article |
| Publicado: |
Springer Nature
Apr2012
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| Acceso en línea: | Ver este registro en EBSCOhost |
| fields | @attributes: recordID: 1 pdfLink: plink: https://search.ebscohost.com/login.aspx?direct=true&db=ccm&AN=104534374&site=ehost-live header: @attributes: shortDbName: ccm uiTerm: 104534374 longDbName: CINAHL Complete uiTag: AN controlInfo: bkinfo: dissinfo: jinfo: jid: 09387994 NPH jtl: European Radiology issn: 09387994 maglogo: N pubinfo: dt: Apr2012 vid: 22 iid: 4 pid: 237 pub: Springer Nature place: New York, New York artinfo: ui: 104534374 104534374 NLM22101800 2011490212 10.1007/s00330-011-2326-9 NLM22101800 104534374 ppf: 855 ppct: 9 formats: fmt: @attributes: type: P tig: atl: Prediction for steatosis in type-2 diabetes: clinico-biological markers versus 1H-MR spectroscopy. aug: au: Guiu B Crevisy-Girod E Binquet C Duvillard L Masson D Lepage C Hamza S Krausé D Verges B Minello A Cercueil JP Hillon P Petit JM Guiu, Boris Crevisy-Girod, Elodie Binquet, Christine Duvillard, Laurence Masson, David Lepage, Côme Hamza, Samia affil: INSERM U866, University of Burgundy, BP 87900, 21079, Dijon, France sug: subj: Adiponectin Blood Diabetes Mellitus, Type 2 Diagnosis Fatty Liver Diagnosis Magnetic Resonance Spectroscopy Methods Carrier Proteins Analysis Triglycerides Analysis Adult Aged Aged, 80 and Over Biological Markers Blood Diabetes Mellitus, Type 2 Blood Diabetes Mellitus, Type 2 Epidemiology Fatty Liver Blood Fatty Liver Epidemiology Female France Human Male Middle Age Prevalence Prognosis Protons Diagnostic Use Risk Assessment Risk Factors Sensitivity and Specificity Adult: 19-44 years Aged: 65+ years Aged, 80 & over Middle Aged: 45-64 years Female Male ab: Objectives: The SteatoTest, fatty liver index (FLI) and hepatic steatosis index (HSI) are clinico-biological scores of steatosis validated in general or selected populations. Serum adiponectin (s-adiponectin) and retinol binding protein 4 (s-RBP4) are adipokines that could predict liver steatosis. We investigated whether the Steatotest, FLI, HSI, s-adiponectin and s-RBP4 could be valid predictors of liver steatosis in type-2 diabetic (T2D) patients.Methods: We enrolled 220 consecutive T2D patients. Reference standard was 3.0 T (1)H-MR spectroscopy (corrected for T1 and T2 decays). Intraclass correlation coefficients (ICCs), Kappa statistic measures of agreement, receiver operating characteristic (ROC) curves were assessed.Results: Median liver fat content was 91 mg triglyceride/g liver tissue (range: 0-392). ICCs among the Steatotest, FLI, HSI, s-adiponectin, s-RBP4 and spectroscopy were low: 0.384, 0.281, 0.087, -0.297 and 0.048. Agreement between scores and spectroscopy was poor (Kappa range: 0.042-0.281). The areas under the ROC curves were low: 0.674, 0.647, 0.637, 0.616 and 0.540. S-adiponectin and s-RBP4 levels were strongly related to the presence of diabetic nephropathy (P = 0.0037 and P = 0.004; Mann-Whitney).Conclusion: The SteatoTest, FLI, HSI, s-adiponectin, s-RBP4 are not valid predictors of steatosis in T2D patients. Clino-biological markers cannot replace (1)H-MR spectroscopy for the assessment of liver fat in this population.Key Points: (1) H-MR spectrosopy can reliably estimate the weight fraction of liver steatosis. Type-2 diabetes provides an interesting model for assessing liver steatosis. Clinico-biological markers seem to be invalid predictors for steatosis in type-2 diabetes. pubtype: Academic Journal doctype: research Journal Article ougenre: Article language: English refInfo: holdings: @attributes: islocal: N |
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