Patient-specific simulations of transcatheter aortic valve stent implantation.
Transcatheter aortic valve implantation (TAVI) enables treatment of aortic stenosis with no need for open heart surgery. According to current guidelines, only patients considered at high surgical risk can be treated with TAVI. In this study, patient-specific analyses were performed to explore the fe...
| Publicado en: | Medical & Biological Engineering & Computing Vol. 50; no. 2; pp. 183 - 193 |
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| Autores principales: | , , , , , , , , , , , , , , , , , |
| Formato: | research Journal Article |
| Publicado: |
Springer Nature
Feb2012
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| Acceso en línea: | Ver este registro en EBSCOhost |
| fields | @attributes: recordID: 1 pdfLink: plink: https://search.ebscohost.com/login.aspx?direct=true&db=ccm&AN=104534522&site=ehost-live header: @attributes: shortDbName: ccm uiTerm: 104534522 longDbName: CINAHL Complete uiTag: AN controlInfo: bkinfo: dissinfo: jinfo: jid: 01400118 PO0 jtl: Medical & Biological Engineering & Computing issn: 01400118 maglogo: N pubinfo: dt: Feb2012 vid: 50 iid: 2 pid: 237 pub: Springer Nature place: New York, New York artinfo: ui: 104534522 NLM22286953 2011490404 10.1007/s11517-012-0864-1 NLM22286953 104534522 ppf: 183 ppct: 10 formats: fmt: @attributes: type: P tig: atl: Patient-specific simulations of transcatheter aortic valve stent implantation. aug: au: Capelli C Bosi GM Cerri E Nordmeyer J Odenwald T Bonhoeffer P Migliavacca F Taylor AM Schievano S Capelli, C Bosi, G M Cerri, E Nordmeyer, J Odenwald, T Bonhoeffer, P Migliavacca, F Taylor, A M Schievano, S affil: Centre for Cardiovascular Imaging, UCL Institute ofCardiovascular Science, Great Ormond Street Hospital for Children, Great Ormond Street, London WC1N 3JH, UK sug: subj: Aortic Valve Stenosis Surgery Heart Valve Prosthesis Methods Models, Biological Pilot Studies Heart Catheterization Methods Heart Valve Prosthesis Human Male Patient Selection Patient Simulation Prosthesis Failure Stents Minimally Invasive Procedures Methods Young Adult Male ab: Transcatheter aortic valve implantation (TAVI) enables treatment of aortic stenosis with no need for open heart surgery. According to current guidelines, only patients considered at high surgical risk can be treated with TAVI. In this study, patient-specific analyses were performed to explore the feasibility of TAVI in morphologies, which are currently borderline cases for a percutaneous approach. Five patients were recruited: four patients with failed bioprosthetic aortic valves (stenosis) and one patient with an incompetent, native aortic valve. Three-dimensional models of the implantation sites were reconstructed from computed tomography images. Within these realistic geometries, TAVI with an Edwards Sapien stent was simulated using finite element (FE) modelling. Engineering and clinical outcomes were assessed. In all patients, FE analysis proved that TAVI was morphologically feasible. After the implantation, stress distribution showed no risks of immediate device failure and geometric orifice areas increased with low risk of obstruction of the coronary arteries. Maximum principal stresses in the arterial walls were higher in the model with native outflow tract. FE analyses can both refine patient selection and characterise device mechanical performance in TAVI, overall impacting on procedural safety in the early introduction of percutaneous heart valve devices in new patient populations. pubtype: Academic Journal doctype: research Journal Article ougenre: Article language: English refInfo: holdings: @attributes: islocal: N |
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