Asymptotic model of electrical stimulation of nerve fibers.
We present a novel theory and computational algorithm for modeling electrical stimulation of nerve fibers in three dimensions. Our approach uses singular perturbation to separate the full 3D boundary value problem into a set of 2D "transverse" problems coupled with a 1D "longitudinal" problem. The r...
| Publicado en: | Medical & Biological Engineering & Computing Vol. 50; no. 3; pp. 243 - 252 |
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| Autores principales: | , , , , , |
| Formato: | Journal Article |
| Publicado: |
Springer Nature
Mar2012
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| Acceso en línea: | Ver este registro en EBSCOhost |
| fields | @attributes: recordID: 1 pdfLink: plink: https://search.ebscohost.com/login.aspx?direct=true&db=ccm&AN=104534773&site=ehost-live header: @attributes: shortDbName: ccm uiTerm: 104534773 longDbName: CINAHL Complete uiTag: AN controlInfo: bkinfo: dissinfo: jinfo: jid: 01400118 PO0 jtl: Medical & Biological Engineering & Computing issn: 01400118 maglogo: N pubinfo: dt: Mar2012 vid: 50 iid: 3 pid: 237 pub: Springer Nature place: New York, New York artinfo: ui: 104534773 NLM22350436 2011490740 10.1007/s11517-012-0870-3 NLM22350436 104534773 ppf: 243 ppct: 9 formats: fmt: @attributes: type: P tig: atl: Asymptotic model of electrical stimulation of nerve fibers. aug: au: Cranford JP Kim BJ Krassowska Neu W Cranford, Jonathan P Kim, Brian J Neu, Wanda Krassowska affil: Department of Biomedical Engineering, Duke University, Box 90281, Durham, NC 27708-0281, USA sug: subj: Electric Stimulation Methods Models, Biological Nerve Fibers Physiology Algorithms Membrane Potentials Physiology ab: We present a novel theory and computational algorithm for modeling electrical stimulation of nerve fibers in three dimensions. Our approach uses singular perturbation to separate the full 3D boundary value problem into a set of 2D "transverse" problems coupled with a 1D "longitudinal" problem. The resulting asymptotic model contains not one but two activating functions (AF): the longitudinal AF that drives the slow development of the mean transmembrane potential and the transverse AF that drives the rapid polarization of the fiber in the transverse direction. The asymptotic model is implemented for a prototype 3D cylindrical fiber with a passive membrane in an isotropic extracellular region. The validity of this approach is tested by comparing the numerical solution of the asymptotic model to the analytical solutions. The results show that the asymptotic model predicts steady-state transmembrane potential directly under the electrodes with the root mean square error of 0.539 mV, i.e., 1.04% of the maximum transmembrane potential. Thus, this work has created a computationally efficient algorithm that facilitates studies of the complete spatiotemporal dynamics of nerve fibers in three dimensions. pubtype: Academic Journal doctype: Journal Article ougenre: Article language: English refInfo: holdings: @attributes: islocal: N |
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