Dynamic gadolinium-enhanced magnetic resonance imaging allows accurate assessment of the synovial inflammatory activity in rheumatoid arthritis knee joints: a comparison with synovial histology.
Objective: To determine whether dynamic contrast-enhanced magnetic resonance imaging (DCE-MRI) evaluated using semi-automatic image processing software can accurately assess synovial inflammation in rheumatoid arthritis (RA) knee joints. Methods: In 17 RA patients undergoing knee surgery, the averag...
| Publicado en: | Scandinavian Journal of Rheumatology Vol. 41; no. 2; pp. 89 - 95 |
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| Autores principales: | , , , , , , , , , , , , |
| Formato: | research Journal Article |
| Publicado: |
Taylor & Francis Ltd
Mar2012
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| Acceso en línea: | Ver este registro en EBSCOhost |
| fields | @attributes: recordID: 1 pdfLink: plink: https://search.ebscohost.com/login.aspx?direct=true&db=ccm&AN=104540448&site=ehost-live header: @attributes: shortDbName: ccm uiTerm: 104540448 longDbName: CINAHL Complete uiTag: AN controlInfo: bkinfo: dissinfo: jinfo: jid: 03009742 1GI jtl: Scandinavian Journal of Rheumatology issn: 03009742 maglogo: Y pubinfo: dt: Mar2012 vid: 41 iid: 2 pid: 377 pub: Taylor & Francis Ltd place: Philadelphia, Pennsylvania artinfo: ui: 104540448 NLM22283139 2011499712 10.3109/03009742.2011.608375 NLM22283139 104540448 ppf: 89 ppct: 6 formats: tig: atl: Dynamic gadolinium-enhanced magnetic resonance imaging allows accurate assessment of the synovial inflammatory activity in rheumatoid arthritis knee joints: a comparison with synovial histology. aug: au: Axelsen, Mb Stoltenberg, M Poggenborg, Rp Kubassova, O Boesen, M Bliddal, H Hørslev-Petersen, K Hanson, Lg Ostergaard, M Axelsen, M B Poggenborg, R P Hanson, L G Østergaard, M affil: Department of Rheumatology, Copenhagen University Hospital at Glostrup, Glostrup, Denmark sug: subj: Arthritis, Rheumatoid Diagnosis Magnetic Resonance Imaging Methods Synovitis Diagnosis Adult Aged Aged, 80 and Over Arthritis, Rheumatoid Complications Arthritis, Rheumatoid Radiography Arthroplasty, Replacement, Knee Contrast Media Diagnostic Use Female Elements Diagnostic Use Human Image Interpretation, Computer Assisted Knee Joint Metabolism Knee Joint Pathology Knee Joint Surgery Male Middle Age Observer Bias Reproducibility of Results Synovitis Etiology Synovitis Radiography Young Adult Adult: 19-44 years Aged: 65+ years Aged, 80 & over Middle Aged: 45-64 years Female Male ab: Objective: To determine whether dynamic contrast-enhanced magnetic resonance imaging (DCE-MRI) evaluated using semi-automatic image processing software can accurately assess synovial inflammation in rheumatoid arthritis (RA) knee joints. Methods: In 17 RA patients undergoing knee surgery, the average grade of histological synovial inflammation was determined from four biopsies obtained during surgery. A preoperative series of T(1)-weighted dynamic fast low-angle shot (FLASH) MR images was obtained. Parameters characterizing contrast uptake dynamics, including the initial rate of enhancement (IRE), were generated by the software in three different areas: (I) the entire slice (Whole slice); (II) a manually outlined region of interest (ROI) drawn quickly around the joint, omitting large artefacts such as blood vessels (Quick ROI); and (III) a manually outlined ROI following the synovial capsule of the knee joint (Precise ROI). Intra- and inter-reader agreement was assessed using the intra-class correlation coefficient (ICC). Results: The IRE from the Quick ROI and the Precise ROI revealed high correlations to the grade of histological inflammation (Spearman's correlation coefficient (rho) = 0.70, p = 0.001 and rho = 0.74, p = 0.001, respectively). Intra- and inter-reader ICCs were very high (0.93-1.00). No Whole slice parameters were correlated to histology. Conclusion: DCE-MRI provides fast and accurate assessment of synovial inflammation in RA patients. Manual outlining of the joint to omit large artefacts is necessary. pubtype: Academic Journal doctype: research Journal Article ougenre: Article language: English refInfo: holdings: @attributes: islocal: N |
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