Feasibility of continuous multiorgan variability analysis in the intensive care unit.

Abstract: Purpose: The aim of the study was to evaluate the feasibility of continuous heart and respiratory rate variability (HRV and RRV, respectively) monitoring in critically ill patients derived from electrocardiogram (ECG) and end-tidal capnography (etCO2) waveforms. Methods: Thirty-four patien...

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Publicado en:Journal of Critical Care Vol. 27; no. 2; pp. 218.e9 - 218000000001
Autores principales: Bradley, Beverly, Green, Geoffrey C., Batkin, Izmail, Seely, Andrew J.E.
Formato: research Journal Article
Publicado: Elsevier B.V. Apr2012
Acceso en línea:Ver este registro en EBSCOhost
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        atl: Feasibility of continuous multiorgan variability analysis in the intensive care unit.
      aug:
        au:
          Bradley, Beverly
          Green, Geoffrey C.
          Batkin, Izmail
          Seely, Andrew J.E.
        affil: Ottawa Hospital Research Institute, Ottawa, Ontario, Canada, K1H 8L6
      sug:
        subj:
          Intensive Care Units
          Patient Assessment
          Multiple Organ Dysfunction Syndrome Diagnosis
          Critical Care
          Critically Ill Patients
          Heart Rate Evaluation
          Capnography
          Tidal Volume Evaluation
          Human
          Electrocardiography
          Descriptive Statistics
          Carbon Dioxide Analysis
      ab: Abstract: Purpose: The aim of the study was to evaluate the feasibility of continuous heart and respiratory rate variability (HRV and RRV, respectively) monitoring in critically ill patients derived from electrocardiogram (ECG) and end-tidal capnography (etCO2) waveforms. Methods: Thirty-four patients (age, 56.5 ± 15.9 years; Acute Physiology and Chronic Health Evaluation II score, 22.8 ± 6.7) underwent continuous recording of ECG and etCO2 waveforms from intensive care unit admission and intubation to discharge or maximum of 14 days. Overlapping 5-minute windows were analyzed with a wide range of variability measures (time, frequency, entropy, and scale-invariant and nonlinear domains). Waveform data quality, presence of disconnections and arrhythmias, quality of beat and breath detection, and subsequent variability computations were evaluated. Results: Patients were enrolled for 11.0 ± 3.6 days. The proportion of missing waveform data among all patients was (median [interquartile range, maximum]) 2.9% (1.3%-9.7%, 36.4%) for ECG and 3.1% (1.1%-11.4%, 84.5%) for etCO2. Heart rate variability data loss (ie, proportion of windows removed) was 1.3% (1.0%-2.1%, 5.9%) due to disconnection, 0.6% (0.1%-3.9%, 39.5%) due to atrial fibrillation, and 6.6% (1.4%-17.9%, 89.0%) due to data cleaning. Respiratory rate variability data loss was 7.3% (2.9%-11.6%, 47.7%) due to disconnection (or apnea) and 5.5% (2.9%-8.4%, 56.4%) due to cleaning. Continuous individualized multiorgan variability analysis processing resulted in HRV and RRV computations for 81.2% ± 25.0% and 87.5% ± 11.9% of available ECG and etCO2 waveform data, respectively. Conclusions: The quality of continuously recorded ECG and etCO2 waveforms in critically ill patients is adequate for subsequent continuous variability monitoring in this pilot study. The clinical utility of continuous variability analysis merits further investigation.
      pubtype: Academic Journal
      doctype:
        research
        Journal Article
      ougenre: Article
    language: English
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