The immunomodulatory properties of viable Lactobacillus salivarius ssp . salivarius CECT5713 are not restricted to the large intestine.
Purpose: The aim of this study was to better characterise the biological effects of Lactobacillus salivarius ssp . salivarius CECT5713, a probiotic with immunomodulatory properties. Methods: Live or dead probiotic was assayed in the TNBS model of rat colitis to determine whether viability was a requ...
| Publicado en: | European Journal of Nutrition Vol. 51; no. 3; pp. 365 - 375 |
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| Autores principales: | , , , , , , , , , , , , |
| Formato: | pictorial research tables/charts Journal Article |
| Publicado: |
Springer Nature
Apr2012
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| Acceso en línea: | Ver este registro en EBSCOhost |
| fields | @attributes: recordID: 1 pdfLink: plink: https://search.ebscohost.com/login.aspx?direct=true&db=ccm&AN=104541527&site=ehost-live header: @attributes: shortDbName: ccm uiTerm: 104541527 longDbName: CINAHL Complete uiTag: AN controlInfo: bkinfo: dissinfo: jinfo: jid: 14366207 CR0 jtl: European Journal of Nutrition issn: 14366207 maglogo: N pubinfo: dt: Apr2012 vid: 51 iid: 3 pid: 237 pub: Springer Nature place: New York, New York artinfo: ui: 104541527 73823391 10.1007/s00394-011-0221-4 104541527 ppf: 365 ppct: 10 formats: fmt: @attributes: type: P tig: atl: The immunomodulatory properties of viable Lactobacillus salivarius ssp . salivarius CECT5713 are not restricted to the large intestine. aug: au: Arribas, Belén Garrido-Mesa, Natividad Perán, Laura Camuesco, Desirée Comalada, Mònica Bailón, Elvira Olivares, Mónica Xaus, Jordi Kruidenier, Laurens Sanderson, Ian Zarzuelo, Antonio Rodríguez-Cabezas, Maria Gálvez, Julio affil: Centro de Investigaciones Biomédicas en Red, Enfermedades Hepáticas y Digestivas (CIBER-EHD), Department of Pharmacology, Center for Biomedical Research, University of Granada, Avenida del Conocimiento s/n 18100 Armilla Spain sug: subj: Lactobacillus Probiotics Pharmacodynamics Immune System Drug Effects Antiinflammatory Agents Pharmacodynamics Funding Source Alternative Therapies In Vivo Studies Animal Studies Rats Colitis Therapy In Vitro Studies Models, Biological Interleukins Metabolism Shock, Septic Therapy Mice Random Assignment Histological Techniques Human Enzyme-Linked Immunosorbent Assay Comparative Studies Descriptive Statistics One-Way Analysis of Variance Post Hoc Analysis Mann-Whitney U Test Data Analysis Software Intestines Drug Effects Epithelium Drug Effects Regeneration ab: Purpose: The aim of this study was to better characterise the biological effects of Lactobacillus salivarius ssp . salivarius CECT5713, a probiotic with immunomodulatory properties. Methods: Live or dead probiotic was assayed in the TNBS model of rat colitis to determine whether viability was a requisite to exert the beneficial effects. In vitro studies were also performed in Caco-2 cells to evaluate its effects on epithelial cell recovery and IL-8 production. Finally, the probiotic was assayed in the LPS model of septic shock in mice to establish its effects when there is an altered systemic immune response. Results: The viability of the probiotic was required for its anti-inflammatory activity. The probiotic inhibited IL-8 production in stimulated Caco-2 cells and facilitated the recovery of damaged intestinal epithelium. In LPS-treated mice, the probiotic inhibited the production of TNFα in plasma and lungs and increased the hepatic glutathione content. These effects were associated with an improvement in the altered production of the T-cell cytokines in splenocytes, by reducing IL-2 and IL-5 and by increasing IL-10. Finally, it reduced the increased plasma IgG production in LPS-treated mice. Conclusion: The anti-inflammatory effects of viable L. salivarius ssp . salivarius CECT5713 are not restricted to the gastrointestinal tract. pubtype: Academic Journal doctype: pictorial research tables/charts Journal Article ougenre: Article language: English refInfo: holdings: @attributes: islocal: N |
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