Within-subject variability during spatial working memory in children with ADHD: an event-related potentials study.
Working memory (WM) dysfunction and increased within-subject variability are known issues in attention deficit/hyperactivity disorder (ADHD) patients. Little is known about the electrophysiological characteristics of this variability. We evaluated behavioral and electrophysiological within-subject v...
| Published in: | European Child & Adolescent Psychiatry Vol. 21; no. 4; pp. 199 - 211 |
|---|---|
| Main Authors: | , , , |
| Format: | research tables/charts Journal Article |
| Published: |
Springer Nature
Apr2012
|
| Online Access: | View this record in EBSCOhost |
| fields | @attributes: recordID: 1 pdfLink: plink: https://search.ebscohost.com/login.aspx?direct=true&db=ccm&AN=104542170&site=ehost-live header: @attributes: shortDbName: ccm uiTerm: 104542170 longDbName: CINAHL Complete uiTag: AN controlInfo: bkinfo: dissinfo: jinfo: jid: 10188827 EJ3 jtl: European Child & Adolescent Psychiatry issn: 10188827 maglogo: N pubinfo: dt: Apr2012 vid: 21 iid: 4 pid: 237 pub: Springer Nature place: New York, New York artinfo: ui: 104542170 73910400 10.1007/s00787-012-0253-1 NLM22311145 104542170 ppf: 199 ppct: 12 formats: fmt: @attributes: type: P tig: atl: Within-subject variability during spatial working memory in children with ADHD: an event-related potentials study. aug: au: Myatchin, I. Lemiere, J. Danckaerts, M. Lagae, L. affil: Department of Woman and Child, Section Paediatric Neurology, University Hospitals KULeuven, Herestraat 49 3000 Leuven Belgium sug: subj: Memory Disorders Attention Deficit Hyperactivity Disorder Task Performance and Analysis Evoked Potentials, Visual Child Adolescence Human Male Female DSM Scales Clinical Assessment Tools Effect Size P-Value Reaction Time Analysis of Variance Electroencephalography Electrophysiology Child: 6-12 years Adolescent: 13-18 years Male Female ab: Working memory (WM) dysfunction and increased within-subject variability are known issues in attention deficit/hyperactivity disorder (ADHD) patients. Little is known about the electrophysiological characteristics of this variability. We evaluated behavioral and electrophysiological within-subject variability taking developmental aspects into account in a group of ADHD patients. Multichannel ( n = 31) event-related potentials (ERP) were measured during a visuo-spatial backmatching task; 44 children (8-16 years old) were tested: 22 children with ADHD, combined ( n = 17) and inattentive ( n = 5) type, and 22 age- and intelligence-matched control children. One-backmatching (BM1) and two-backmatching (BM2) tasks were performed. Classical behavioral parameters and target and nontarget ERP were compared between groups. In addition, motor response variability and ERP amplitude variability were studied. Age-related changes in both motor response and ERP amplitude variability were analyzed in each group. Attention deficit/hyperactivity disorder children made more commission errors, which was more pronounced in the difficult (BM2) task. No difference between groups was found in ERP amplitude and in motor response variability. However, ADHD patients had higher ERP amplitude variability, which was again more pronounced in the difficult WM task. A delayed maturation of amplitude variability was seen in ADHD patients with a slower than in controls decrease in variability with age. This amplitude variability was correlated with the number of commissions, but in an opposite way for ADHD and control children. Our findings indicate an impaired visuo-spatial WM processing in ADHD children with greater ERP amplitude variability compared to controls. Our results also support the view of a delayed cortical development of visuo-spatial WM circuits in this disorder. pubtype: Academic Journal doctype: research tables/charts Journal Article ougenre: Article language: English refInfo: holdings: @attributes: islocal: N |
|---|