Is methicillin-resistant Staphylococcus aureus involved in community acquired skin and soft tissue infections?: Experience from a tertiary care centre in Mumbai...[corrected] [published erratum appears in J POSTGRAD MED 2012 Apr-Jun;58(2):158]
Background: To improve the empiric antimicrobial therapy of community-acquired (CA) skin and soft tissue infections (SSTIs), it is necessary to generate data on the current spectrum and susceptibility profile of associated bacteria. CA methicillin-resistant Staphylococcus aureus (CA MRSA) is increas...
| Publicado en: | Journal of Postgraduate Medicine Vol. 58; no. 1; pp. 3 - 8 |
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| Autores principales: | , , , , |
| Formato: | research tables/charts Journal Article |
| Publicado: |
Lippincott Williams & Wilkins
Jan-Mar2012
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| Acceso en línea: | Ver este registro en EBSCOhost |
| fields | @attributes: recordID: 1 pdfLink: plink: https://search.ebscohost.com/login.aspx?direct=true&db=ccm&AN=104543228&site=ehost-live header: @attributes: shortDbName: ccm uiTerm: 104543228 longDbName: CINAHL Complete uiTag: AN controlInfo: bkinfo: dissinfo: jinfo: jid: 00223859 SUZ jtl: Journal of Postgraduate Medicine issn: 00223859 maglogo: N pubinfo: dt: Jan-Mar2012 vid: 58 iid: 1 pid: 433 pub: Lippincott Williams & Wilkins place: Baltimore, Maryland artinfo: ui: 104543228 73947477 10.4103/0022-3859.93245 NLM22387641 104543228 ppf: 3 ppct: 5 formats: tig: atl: Is methicillin-resistant Staphylococcus aureus involved in community acquired skin and soft tissue infections?: Experience from a tertiary care centre in Mumbai...[corrected] [published erratum appears in J POSTGRAD MED 2012 Apr-Jun;58(2):158] aug: au: Phakade, R. S. Nataraj, G. Kuyare, S. K. Khopkar, U. S. Mehta, P. R. affil: Department of Microbiology, Seth G. S. Medical College and KEM Hospital, Mumbai, India sug: subj: Community-Acquired Infections Methicillin-Resistant Staphylococcus Aureus Soft Tissue Infections Etiology Academic Medical Centers Adolescence Adult Chi Square Test Clindamycin Community-Acquired Infections Classification Community-Acquired Infections Microbiology Data Analysis Software Female Human India Male Middle Age Prospective Studies Pyoderma Retrospective Design Adolescent: 13-18 years Adult: 19-44 years Middle Aged: 45-64 years Female Male ab: Background: To improve the empiric antimicrobial therapy of community-acquired (CA) skin and soft tissue infections (SSTIs), it is necessary to generate data on the current spectrum and susceptibility profile of associated bacteria. CA methicillin-resistant Staphylococcus aureus (CA MRSA) is increasingly being reported in SSTIs in India and globally. Aims: The present study was undertaken to determine the bacterial profile of CA-SSTIs, to know the contribution of MRSA in these infections, to determine inducible clindamycin resistance in S. aureus and to compare the resistance patterns of isolates from hospital-acquired (HA) SSTIs. Materials and Methods: Eight hundred and twenty patients with CA SSTIs were prospectively studied. Pus samples were cultured and antimicrobial susceptibility pattern determined. Inducible clindamycin resistance was detected by D-test. Laboratory records were analyzed retrospectively to generate data on HA SSTIs. Results: 619 isolates were recovered in CA-SSTIs, of which S. aureus (73%) and Streptococci (12%) were the most common. Pseudomonas aeruginosa (28%) and Acinetobacter spp (18%) were the predominant HA-SSTI pathogens. Susceptibility of CA S. aureus to antibiotics tested was, penicillin (6%), co-trimoxazole (20%), ciprofloxacin (37%), cefazolin (100%), erythromycin (84%), clindamycin (97%), gentamicin (94%) and fusidic acid (95%). No MRSA was found in CA SSTIs whereas 45% of HA S. aureus strains were methicillin-resistant. HA strains demonstrated significantly higher resistance as compared to their CA counterparts (P<0.001). D test was positive in 22% of CA S. aureus tested. Conclusions: In CA SSTIs, methicillin-susceptible S. aureus is the predominant pathogen. Penicillinase-resistant penicillins, clindamycin and erythromycin in that order can be used as suitable antimicrobials for empiric therapy. D test should be carried out routinely. No CA MRSA was detected in the present series. pubtype: Academic Journal doctype: research tables/charts Journal Article ougenre: Article language: English refInfo: holdings: @attributes: islocal: N |
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