VEGF and COX-2 Expression in Endometrial Carcinoma.
ABS TRACT Ob jec ti ve: Angiogenesis is a major factor in the development of solid tumors, such as endometrial cancer. Vascular endothelial growth factor (VEGF) and cyclooxygenase-2 (COX-2) are important cytokines that stimulate angiogenesis in vivo. The aim of the current study was to determine VEG...
| Publicado en: | Turkiye Klinikleri Journal of Medical Sciences Vol. 32; no. 1; pp. 80 - 88 |
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| Autores principales: | , , , |
| Formato: | pictorial research tables/charts Journal Article |
| Publicado: |
Turkiye Klinikleri
Feb2012
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| Acceso en línea: | Ver este registro en EBSCOhost |
| fields | @attributes: recordID: 1 pdfLink: plink: https://search.ebscohost.com/login.aspx?direct=true&db=ccm&AN=104544645&site=ehost-live header: @attributes: shortDbName: ccm uiTerm: 104544645 longDbName: CINAHL Complete uiTag: AN controlInfo: bkinfo: dissinfo: jinfo: jid: 13000292 1VOP jtl: Turkiye Klinikleri Journal of Medical Sciences issn: 13000292 maglogo: N pubinfo: dt: Feb2012 vid: 32 iid: 1 pid: 67298 pub: Turkiye Klinikleri artinfo: ui: 104544645 2011503889 10.5336/medsci.2010-22258 104544645 ppf: 80 ppct: 8 formats: fmt: @attributes: type: P tig: atl: VEGF and COX-2 Expression in Endometrial Carcinoma. aug: au: Erol, Y. Azize Göksu Tokyol, Çigdem Ariöz, Dagistan Tolga Aktepe, Fatma affil: Department of Medical Genetics, Süleyman Demirel University, Faculty of Medicine, Isparta sug: subj: Adenocarcinoma Pathology Cox-2 Inhibitors Endometrial Neoplasms Pathology Neovascularization, Physiologic Vascular Endothelial Growth Factors Data Analysis Software Funding Source Human Immunohistochemistry P-Value Retrospective Design Spearman's Rank Correlation Coefficient Staining and Labeling ab: ABS TRACT Ob jec ti ve: Angiogenesis is a major factor in the development of solid tumors, such as endometrial cancer. Vascular endothelial growth factor (VEGF) and cyclooxygenase-2 (COX-2) are important cytokines that stimulate angiogenesis in vivo. The aim of the current study was to determine VEGF and COX-2 expression in endometrial adenocarcinomas and to investigate the relationship between these parameters and clinicopathologic parameters. Material and Methods: Sections obtained from paraffin-embedded tissues in archive material of 23 patients who were diagnosed with endometrial carcinoma were retrospectively evaluated. VEGF and COX-2 expression levels in tumor cells and surrounding stroma on the tumor samples were determined by immunohistochemistry. Results: VEGF and COX-2 were expressed both in the cytoplasm of tumor cells and in the stromal cells, but in a lower degree. There was a significant positive correlation between VEGF expressions of cancer cells and the stroma (r= 0.705, p< 0.01). A negative correlation was found between histological grade of the tumor and VEGF expression of cancer cells (r= -0.622, p= 0.002). A negative correlation was determined between myometrial invasion of the tumor and COX-2 expression of cancer cells (r= -0.441, p= 0.035). Conclusion: Both VEGF and COX-2 were expressed by both tumor cells and stromal cells in endometrial cancer. While VEGF expression showed a negative correlation with the tumor grade, COX-2 expression exhibited a negative correlation with the myometrial invasion of the tumor. No correlation was determined between their expressions and other clinicopathologic prognostic parameters. pubtype: Academic Journal doctype: pictorial research tables/charts Journal Article ougenre: Article language: English refInfo: holdings: @attributes: islocal: N |
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