Cytoreductive Surgery Followed by Hyperthermic Intraperitoneal Chemotherapy: Morbidity and Mortality Analysis of Our Patients.
ABS TRACT Objective: The purpose of this study was to analyze the morbidity and mortality of cytoreductive surgery (CRS) plus hyperthermic intraperitoneal chemotherapy (HIPEC) and early postoperative intraperitoneal chemotherapy (EPIC) with closed abdomen technique in the treatment of peritoneal sur...
| Publicado en: | Turkiye Klinikleri Journal of Medical Sciences Vol. 32; no. 1; pp. 162 - 171 |
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| Autores principales: | , , , , , , , , , , , |
| Formato: | pictorial research tables/charts Journal Article |
| Publicado: |
Turkiye Klinikleri
Feb2012
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| Acceso en línea: | Ver este registro en EBSCOhost |
| fields | @attributes: recordID: 1 pdfLink: plink: https://search.ebscohost.com/login.aspx?direct=true&db=ccm&AN=104544655&site=ehost-live header: @attributes: shortDbName: ccm uiTerm: 104544655 longDbName: CINAHL Complete uiTag: AN controlInfo: bkinfo: dissinfo: jinfo: jid: 13000292 1VOP jtl: Turkiye Klinikleri Journal of Medical Sciences issn: 13000292 maglogo: N pubinfo: dt: Feb2012 vid: 32 iid: 1 pid: 67298 pub: Turkiye Klinikleri artinfo: ui: 104544655 2011503899 10.5336/medsci.2011-23538 104544655 ppf: 162 ppct: 9 formats: fmt: @attributes: type: P tig: atl: Cytoreductive Surgery Followed by Hyperthermic Intraperitoneal Chemotherapy: Morbidity and Mortality Analysis of Our Patients. aug: au: Karadayi, Kürsat Turan, Mustafa Karadayi, Sule Kiliçkap, Saadettin Büyükçelik, Abdullah Sarkis, Cihat Yücel, Birsen Boztosun, Abdullah Çetin, Meral Yilmaz, Abdulkerim Yanik, Ali Sen, Metin affil: Department of General Surgery, Cumhuriyet University Faculty of Medicine, Sivas sug: subj: Antineoplastic Agents, Combined Administration and Dosage Carcinoma Drug Therapy Chemotherapy, Cancer Neoplasms Drug Therapy Neoplasms Surgery Perfusion, Regional Peritoneum Pathology Administration, Intraperitoneal Adult Aged Aged, 80 and Over Combined Modality Therapy Descriptive Statistics Female Heat Therapeutic Use Human Male Middle Age Morbidity Mortality Treatment Outcomes Adult: 19-44 years Aged: 65+ years Aged, 80 & over Middle Aged: 45-64 years Female Male ab: ABS TRACT Objective: The purpose of this study was to analyze the morbidity and mortality of cytoreductive surgery (CRS) plus hyperthermic intraperitoneal chemotherapy (HIPEC) and early postoperative intraperitoneal chemotherapy (EPIC) with closed abdomen technique in the treatment of peritoneal surface malignancies. Material and Methods: Twenty-six patients (8 with ovarian cancer, 7 peritoneal mesothelioma, 6 colorectal cancer, 3 uterine sarcoma, 1 peritoneal carcinoma and 1 with gastric cancer) underwent 27 procedures. Peritonectomy was performed with complete removal of all the involved visceral and parietal peritoneum. HIPEC was performed with the closed abdominal technique using preheated (42.5°C) perfusate for 60 minutes. EPIC was continued for postoperative 5 days. Results: All patients underwent resection of the lesions. Total peritonectomy was performed in 12 patients, while subtotal or partial peritonectomy was carried out in 14 according to the spread of carcinomatosis. Completeness of cytoreduction score of our patients was 0 in 18 patients, 1 in 6 patients and 2 in 2 patients. Major morbidity developed in 7 patients (27%). CRS+ HIPEC+ EPIC yielded acceptable morbidity and mortality rates. Of the 26 patients, 20 (77%) were alive without evidence of disease with a mean follow-up period of 13 ± 6 months. Overall 1 year survival was 60%. Conclusion: Cytoreductive approach combined with intraperitoneal chemotherapy prolongs survival in selected patients with peritoneal carcinomatosis (PC) with acceptable morbidity and mortality. pubtype: Academic Journal doctype: pictorial research tables/charts Journal Article ougenre: Article language: English refInfo: holdings: @attributes: islocal: N |
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