| Sumario: | ABS TRACT Pa ro xe ti ne is an an ti dep res sant agent, which af fects vi a se lec ti ve in hi bi ti on of se ro to - nin re up ta ke. It is wi dely used for the tre at ment of dep res si on, ob ses si ve com pul si ve di sor der, pa - nic di sor der and an xi ety di sor der. Alt ho ugh it has low si de ef fects and a high sa fety pro fi le, so me ca ses of se ve re to xic he pa ti tis as so ci a ted with pa ro xe ti ne ha ve be en re por ted. He pa to to xi city can be he pa to cel lu lar, cho les ta tic or mi xed type. It is ge ne rally idi osyn cra tic and un pre dic tab le, ho we ver pa ti ents with high risk such as co e xis ting li ver di se a se and use of ot her po ten ti al he pa to to xic drugs, sho uld be mo ni to red ca re fully for he pa to to xi city whi le using this drug. He re we re port a ca se of seve re to xic he pa ti tis re la ted to use of pa ro xe ti ne. The pa ti ent re co verd comp le tely af ter the the drug was stop ped.
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