Optimization of myocardial nulling in pediatric cardiac MRI.
Background: Current protocols to determine optimal nulling time in late enhancement imaging using adult techniques may not apply to children.Objective: To determine the optimal nulling time in anesthetised children, with the hypothesis that this occurs earlier than in adults.Materials and Methods: S...
| Publicado en: | Pediatric Radiology Vol. 42; no. 4; pp. 431 - 440 |
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| Autores principales: | , , , , , , , , , |
| Formato: | research Journal Article |
| Publicado: |
Springer Nature
Apr2012
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| Acceso en línea: | Ver este registro en EBSCOhost |
| fields | @attributes: recordID: 1 pdfLink: plink: https://search.ebscohost.com/login.aspx?direct=true&db=ccm&AN=104545905&site=ehost-live header: @attributes: shortDbName: ccm uiTerm: 104545905 longDbName: CINAHL Complete uiTag: AN controlInfo: bkinfo: dissinfo: jinfo: jid: 03010449 O03 jtl: Pediatric Radiology issn: 03010449 maglogo: N pubinfo: dt: Apr2012 vid: 42 iid: 4 pid: 237 pub: Springer Nature place: New York, New York artinfo: ui: 104545905 NLM22006532 2011505956 10.1007/s00247-011-2276-z NLM22006532 104545905 ppf: 431 ppct: 9 formats: fmt: @attributes: type: P tig: atl: Optimization of myocardial nulling in pediatric cardiac MRI. aug: au: Tham EB Hung RW Myers KA Crawley C Noga ML Tham, Edythe B Hung, Ryan W Myers, Kimberley A Crawley, Cinzia Noga, Michelle L affil: Department of Pediatrics, Division of Pediatric Cardiology, Stollery Children's Hospital, University of Alberta, Walter C Mackenzie Health Science Centre, 8440 112th St, Edmonton, Alberta, Canada sug: subj: Elements Administration and Dosage Elements Diagnostic Use Heart Defects, Congenital Pathology Image Enhancement Methods Magnetic Resonance Angiography Methods Child, Preschool Contrast Media Administration and Dosage Female Human Infant Reproducibility of Results Sensitivity and Specificity Child, Preschool: 2-5 years Infant: 1-23 months Female ab: Background: Current protocols to determine optimal nulling time in late enhancement imaging using adult techniques may not apply to children.Objective: To determine the optimal nulling time in anesthetised children, with the hypothesis that this occurs earlier than in adults.Materials and Methods: Sedated cardiac MRI was performed in 12 children (median age: 12 months, range: 1-60 months). After gadolinium administration, scout images at 2, 3, 4 and 10 min and phase sensitive inversion recovery (PSIR) images from 5 to 10 min were obtained. Signal-to-noise ratio (SNR) and inversion time (TI) were determined. Quality of nulling was assessed according to a grading score by three observers. Data was analysed using linear regression, Kruskal-Wallis and quadratic-weighted kappa statistics.Results: One child with a cardiomyopathy had late enhancement. Good agreement in nulling occurred for scout images at 2 (κ = 0.69) and 3 (κ = 0.66) min and moderate agreement at 4 min (κ = 0.57). Agreement of PSIR images was moderate at 7 min (κ = 0.44) and poor-fair at other times. There were significant correlations between TI and scout time (r = 0.61, P < 0.0001), and SNR and kappa (r = 0.22, P = 0.017).Conclusion: Scout images at 2-4 min can be used to determine the TI with little variability. Image quality for PSIR images was highest at 7 min and SNR optimal at 7-9 min. TI increases with time and should be adjusted frequently during imaging. Thus, nulling times in children differ from nulling times in adults when using standard adult techniques. pubtype: Academic Journal doctype: research Journal Article ougenre: Article language: English refInfo: holdings: @attributes: islocal: N |
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