Mixed-effect circadian rhythm model for human erythrocyte acetylcholinesterase activity-application to the proof of concept of cholinesterase inhibition by acorn extract in healthy subjects with galantamine as positive control.
Purpose: The aim of this study was to develop a non-linear mixed effect circadian rhythm model of acetylcholinesterase (AChE) activity variation and to evaluate the inhibitory effect of acorn extract (2 g) and galantamine (16 mg), used as positive control, on human AChE in red blood cells (RBC). Met...
| Publicado en: | European Journal of Clinical Pharmacology Vol. 68; no. 5; pp. 599 - 606 |
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| Autores principales: | , , , , |
| Formato: | equations & formulas research tables/charts randomized controlled trial Journal Article |
| Publicado: |
Springer Nature
May2012
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| Acceso en línea: | Ver este registro en EBSCOhost |