The size of large adipose cells is a predictor of insulin resistance in first-degree relatives of type 2 diabetic patients.
Early studies reported that the size of adipose cells correlates with insulin resistance. However, a recent study comparing moderately obese, sensitive and resistant subjects, with comparable BMI (~30), did not detect any significant difference in the size of the large cells, but rather a smaller pr...
| Published in: | Obesity (19307381) Vol. 20; no. 5; pp. 932 - 939 |
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| Main Authors: | , , , , , , , , , |
| Format: | research Journal Article |
| Published: |
Wiley-Blackwell
May2012
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| Online Access: | View this record in EBSCOhost |
| fields | @attributes: recordID: 1 pdfLink: plink: https://search.ebscohost.com/login.aspx?direct=true&db=ccm&AN=104558904&site=ehost-live header: @attributes: shortDbName: ccm uiTerm: 104558904 longDbName: CINAHL Complete uiTag: AN controlInfo: bkinfo: dissinfo: jinfo: jid: 19307381 GSO jtl: Obesity (19307381) issn: 19307381 maglogo: Y pubinfo: dt: May2012 vid: 20 iid: 5 pid: 480 pub: Wiley-Blackwell place: Malden, Massachusetts artinfo: ui: 104558904 NLM22240722 2011535945 10.1038/oby.2011.371 NLM22240722 PMC3457700 104558904 ppf: 932 ppct: 7 formats: tig: atl: The size of large adipose cells is a predictor of insulin resistance in first-degree relatives of type 2 diabetic patients. aug: au: Yang J Eliasson B Smith U Cushman SW Sherman AS Yang, Jian Eliasson, Bjorn Smith, Ulf Cushman, Samuel W Sherman, Arthur S affil: NIDDK Diabetes Branch, National Institutes of Health, Bethesda, Maryland, USA sug: subj: Adipocytes Pathology Cell Physiology Adipose Tissue Pathology Diabetes Mellitus, Type 2 Pathology Insulin Resistance Obesity Pathology Adipocytes Metabolism Adipose Tissue Metabolism Adult Biological Markers Metabolism Blood Glucose Metabolism Body Mass Index Body Weight Diabetes Mellitus, Type 2 Metabolism Female Glucose Tolerance Test Intercellular Signaling Peptides and Proteins Male Middle Age Obesity Complications Obesity Metabolism Pedigree Adult: 19-44 years Middle Aged: 45-64 years Female Male ab: Early studies reported that the size of adipose cells correlates with insulin resistance. However, a recent study comparing moderately obese, sensitive and resistant subjects, with comparable BMI (~30), did not detect any significant difference in the size of the large cells, but rather a smaller proportion of large cells in the resistant subjects, suggesting impaired adipogenesis. We hypothesize that a decreased proportion, rather than the size, of large adipose cells is also associated with insulin resistance in first-degree relatives of type 2 diabetic patients. Thirty-five leaner (BMI 18-34) subjects who were relatively healthy were recruited. Insulin sensitivity was measured by the euglycemic, hyperinsulinemic clamp. Needle biopsies of abdominal subcutaneous fat were assayed for adipose cell size by fitting the cell size distribution with two exponentials and a Gaussian function. The fraction of large cells was defined as the area of the Gaussian peak and the size of the large cells was defined as its center (c(p)). Glucose infusion rate (GIR) and c(p) were negatively correlated, but insulin sensitivity and the proportion of large cells were not correlated. BMI and c(p) were also strongly correlated, but a relationship of modest correlation between the cell size and insulin resistance was still significant after correcting for BMI. In contrast to moderately obese subjects, in the first-degree relatives of type 2 diabetic patients both BMI and the size of the large adipose cells predict the degree of insulin resistance; no correlation is found between the proportion of large adipose cells and insulin resistance. pubtype: Academic Journal doctype: research Journal Article ougenre: Article language: English refInfo: holdings: @attributes: islocal: N |
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