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The role of breast MR imaging in pre-operative determination of invasive disease for ductal carcinoma in situ diagnosed by needle biopsy.

Objectives: To evaluate whether magnetic resonance (MR) imaging features can predict the presence of occult invasion in cases of biopsy-proven pure ductal carcinoma in situ (DCIS).Methods: We retrospectively reviewed 92 biopsy-proven pure DCIS in 92 women who underwent MR imaging. The following MR i...

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Published in:European Radiology Vol. 22; no. 6; pp. 1255 - 1265
Main Authors: Goto M, Yuen S, Akazawa K, Nishida K, Konishi E, Kajihara M, Shinkura N, Yamada K, Goto, Mariko, Yuen, Sachiko, Akazawa, Kentaro, Nishida, Kaori, Konishi, Eiichi, Kajihara, Mariko, Shinkura, Nobuhiko, Yamada, Kei
Format: research Journal Article
Published: Springer Nature Jun2012
Online Access:View this record in EBSCOhost
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      dt: Jun2012
      vid: 22
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      pub: Springer Nature
      place: New York, New York
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        104566339
        NLM22205445
        2011548252
        10.1007/s00330-011-2357-2
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        atl: The role of breast MR imaging in pre-operative determination of invasive disease for ductal carcinoma in situ diagnosed by needle biopsy.
      aug:
        au:
          Goto M
          Yuen S
          Akazawa K
          Nishida K
          Konishi E
          Kajihara M
          Shinkura N
          Yamada K
          Goto, Mariko
          Yuen, Sachiko
          Akazawa, Kentaro
          Nishida, Kaori
          Konishi, Eiichi
          Kajihara, Mariko
          Shinkura, Nobuhiko
          Yamada, Kei
        affil: Departments of Radiology, Graduate School of Medical Science, Kyoto Prefectural University of Medicine, 465 Kajiicho, Kawaramachi Hirokoji, Kamigyoku, 602-8566 Kyoto, Japan
      sug:
        subj:
          Biopsy, Needle Statistics and Numerical Data
          Breast Neoplasms Epidemiology
          Breast Neoplasms Pathology
          Carcinoma, Ductal Epidemiology
          Carcinoma, Ductal Pathology
          Magnetic Resonance Imaging Statistics and Numerical Data
          Adult
          Aged
          Breast Neoplasms Surgery
          Carcinoma, Ductal Surgery
          Female
          Human
          Incidence
          Japan
          Middle Age
          Neoplasm Invasiveness
          Preoperative Care Statistics and Numerical Data
          Prognosis
          Reproducibility of Results
          Risk Assessment
          Risk Factors
          Sensitivity and Specificity
          Adult: 19-44 years
          Aged: 65+ years
          Middle Aged: 45-64 years
          Female
      ab: Objectives: To evaluate whether magnetic resonance (MR) imaging features can predict the presence of occult invasion in cases of biopsy-proven pure ductal carcinoma in situ (DCIS).Methods: We retrospectively reviewed 92 biopsy-proven pure DCIS in 92 women who underwent MR imaging. The following MR imaging findings were compared between confirmed DCIS and invasive breast cancer (IBC): lesion size, type, morphological and kinetic assessments by ACR BI-RADS MRI, and findings of fat-suppressed T2-weighted (FS-T2W) imaging.Results: Sixty-eight of 92 (74%) were non-mass-like enhancements (NMLE) and 24 were mass lesions on MR imaging. Twenty-one of 68 (31%) NMLE and 13 of 24 (54%) mass lesions were confirmed as IBC. In NMLE lesions, large lesions (P = 0.007) and higher signal intensities (SI) on FS-T2W images (P = 0.032) were significantly associated with IBC. Lesion size remained a significant independent predictor of invasion in multivariate analysis (P = 0.032), and combined with FS-T2W SIs showed slightly higher observer performances (area under the curve, AUC, 0.71) than lesion size alone (AUC 0.68). There were no useful findings that enabled the differentiation of mass-type lesions.Conclusions: Breast MR imaging is potentially useful to predict the presence of occult invasion in biopsy-proven DCIS with NMLE.Key Points: MR mammography permits more precise lesion assessment including ductal carcinoma in situ A correct diagnosis of occult invasion before treatment is important for clinicians This study showed the potential of MR mammography to diagnose occult invasion Treatment and/or aggressive biopsy can be given with greater confidence MR mammography can lead to more appropriate management of patients.
      pubtype: Academic Journal
      doctype:
        research
        Journal Article
      ougenre: Article
    language: English
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