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Apparent diffusion coefficient correlation with oesophageal tumour stroma and angiogenesis.

Objective: Because diffusion-weighted imaging (DWI) can predict the prognosis of patients with oesophageal squamous cell carcinoma (ESCC), we hypothesised that apparent diffusion coefficient (ADC) values might be correlated with the collagen content and tumour angiogenesis. The purpose of this study...

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Published in:European Radiology Vol. 22; no. 6; pp. 1172 - 1178
Main Authors: Aoyagi T, Shuto K, Okazumi S, Hayano K, Satoh A, Saitoh H, Shimada H, Nabeya Y, Kazama T, Matsubara H, Aoyagi, Tomoyoshi, Shuto, Kiyohiko, Okazumi, Shinichi, Hayano, Kohichi, Satoh, Asami, Saitoh, Hiroshige, Shimada, Hideaki, Nabeya, Yoshihiro, Kazama, Toshiki, Matsubara, Hisahiro
Format: research Journal Article
Published: Springer Nature Jun2012
Online Access:View this record in EBSCOhost
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      dt: Jun2012
      vid: 22
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      pub: Springer Nature
      place: New York, New York
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        NLM22258519
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        10.1007/s00330-011-2359-0
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          Aoyagi T
          Shuto K
          Okazumi S
          Hayano K
          Satoh A
          Saitoh H
          Shimada H
          Nabeya Y
          Kazama T
          Matsubara H
          Aoyagi, Tomoyoshi
          Shuto, Kiyohiko
          Okazumi, Shinichi
          Hayano, Kohichi
          Satoh, Asami
          Saitoh, Hiroshige
          Shimada, Hideaki
          Nabeya, Yoshihiro
          Kazama, Toshiki
          Matsubara, Hisahiro
        affil: Department of Frontier Surgery, Graduate School of Medicine, Chiba University, 1-8-1 Inohana, Chuo-ku, Chiba-shi, Chiba 260-8670, Japan
      sug:
        subj:
          Carcinoma, Squamous Cell Diagnosis
          Collagen Analysis
          Esophageal Neoplasms Diagnosis
          Gastrointestinal Neoplasms Diagnosis
          Magnetic Resonance Imaging Methods
          Neovascularization, Pathologic Diagnosis
          Aged
          Carcinoma, Squamous Cell Blood Supply
          Carcinoma, Squamous Cell Metabolism
          Esophageal Neoplasms Blood Supply
          Esophageal Neoplasms Metabolism
          Female
          Gastrointestinal Neoplasms Blood Supply
          Gastrointestinal Neoplasms Metabolism
          Human
          Male
          Middle Age
          Neovascularization, Pathologic Metabolism
          Reproducibility of Results
          Sensitivity and Specificity
          Statistics
          Aged: 65+ years
          Middle Aged: 45-64 years
          Female
          Male
      ab: Objective: Because diffusion-weighted imaging (DWI) can predict the prognosis of patients with oesophageal squamous cell carcinoma (ESCC), we hypothesised that apparent diffusion coefficient (ADC) values might be correlated with the collagen content and tumour angiogenesis. The purpose of this study was to determine the correlation between ADC values of ESCC before treatment and oesophageal tumour stroma and angiogenesis.Methods: Seventeen patients with ESCC were enrolled. The ADC values were calculated from the DWI score. Seventeen patients who had undergone oesophagectomy were analysed for tumour stroma, vascular endothelial growth factor (VEGF) and CD34. Tissue collagen was stained with azocarmine and aniline blue to quantitatively analyse the extracellular matrix in cancer stroma. Tissues were stained with VEGF and CD34 to analyse the angiogenesis.Results: The ADC values decreased with stromal collagen growth. We found a negative correlation between the tumour ADC and the amount of stromal collagen (r = -0.729, P = 0.001), i.e. the ADC values decreased with growth of VEGF. We also found a negative correlation between the ADC of the tumours and the amount of VEGF (r = 0.538, P = 0.026).Conclusion: Our results indicated that the ADC value may be a novel prognostic factor and contribute to the treatment of oesophageal cancer.Key Points: • Magnetic resonance apparent diffusion coefficient values inversely indicate tumour stromal collagen • There is also negative correlation between ADCs and vascular endothelial growth factor • ADC values may contribute to the treatment of oesophageal cancer.
      pubtype: Academic Journal
      doctype:
        research
        Journal Article
      ougenre: Article
    language: English
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