Precise measurement of renal filtration and vascular parameters using a two-compartment model for dynamic contrast-enhanced MRI of the kidney gives realistic normal values.
Objective: To model the uptake phase of T(1)-weighted DCE-MRI data in normal kidneys and to demonstrate that the fitted physiological parameters correlate with published normal values.Methods: The model incorporates delay and broadening of the arterial vascular peak as it appears in the capillary be...
| Publicado en: | European Radiology Vol. 22; no. 6; pp. 1320 - 1331 |
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| Autores principales: | , , , , , , , , , |
| Formato: | research Journal Article |
| Publicado: |
Springer Nature
Jun2012
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| Acceso en línea: | Ver este registro en EBSCOhost |
| fields | @attributes: recordID: 1 pdfLink: plink: https://search.ebscohost.com/login.aspx?direct=true&db=ccm&AN=104566358&site=ehost-live header: @attributes: shortDbName: ccm uiTerm: 104566358 longDbName: CINAHL Complete uiTag: AN controlInfo: bkinfo: dissinfo: jinfo: jid: 09387994 NPH jtl: European Radiology issn: 09387994 maglogo: N pubinfo: dt: Jun2012 vid: 22 iid: 6 pid: 237 pub: Springer Nature place: New York, New York artinfo: ui: 104566358 NLM22415410 2011548271 10.1007/s00330-012-2382-9 NLM22415410 104566358 ppf: 1320 ppct: 11 formats: fmt: @attributes: type: P tig: atl: Precise measurement of renal filtration and vascular parameters using a two-compartment model for dynamic contrast-enhanced MRI of the kidney gives realistic normal values. aug: au: Tofts PS Cutajar M Mendichovszky IA Peters AM Gordon I Tofts, Paul S Cutajar, Marica Mendichovszky, Iosif A Peters, A Michael Gordon, Isky affil: Brighton and Sussex Medical School, Falmer, Sussex BN1 9PX, UK sug: subj: Contrast Media Pharmacokinetics Glomerular Filtration Rate Physiology Kidney Physiology Magnetic Resonance Imaging Methods Models, Biological Renal Artery Physiology Renal Circulation Physiology Adult Algorithms Computer Simulation Contrast Media Standards Female Contrast Media Diagnostic Use Great Britain Human Image Enhancement Methods Image Interpretation, Computer Assisted Methods Kidney Anatomy and Histology Magnetic Resonance Imaging Standards Male Reference Values Reproducibility of Results Sensitivity and Specificity Young Adult Adult: 19-44 years Female Male ab: Objective: To model the uptake phase of T(1)-weighted DCE-MRI data in normal kidneys and to demonstrate that the fitted physiological parameters correlate with published normal values.Methods: The model incorporates delay and broadening of the arterial vascular peak as it appears in the capillary bed, two distinct compartments for renal intravascular and extravascular Gd tracer, and uses a small-vessel haematocrit value of 24%. Four physiological parameters can be estimated: regional filtration K ( trans ) (ml min(-1) [ml tissue](-1)), perfusion F (ml min(-1) [100 ml tissue](-1)), blood volume v ( b ) (%) and mean residence time MRT (s). From these are found the filtration fraction (FF; %) and total GFR (ml min(-1)). Fifteen healthy volunteers were imaged twice using oblique coronal slices every 2.5 s to determine the reproducibility.Results: Using parenchymal ROIs, group mean values for renal biomarkers all agreed with published values: K ( trans ): 0.25; F: 219; v ( b ): 34; MRT: 5.5; FF: 15; GFR: 115. Nominally cortical ROIs consistently underestimated total filtration (by ~50%). Reproducibility was 7-18%. Sensitivity analysis showed that these fitted parameters are most vulnerable to errors in the fixed parameters kidney T(1), flip angle, haematocrit and relaxivity.Conclusions: These renal biomarkers can potentially measure renal physiology in diagnosis and treatment.Key Points: • Dynamic contrast-enhanced magnetic resonance imaging can measure renal function. • Filtration and perfusion values in healthy volunteers agree with published normal values. • Precision measured in healthy volunteers is between 7 and 15%. pubtype: Academic Journal doctype: research Journal Article ougenre: Article language: English refInfo: holdings: @attributes: islocal: N |
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