Axonal integrity predicts cortical reorganisation following cervical injury.
Background: Traumatic spinal cord injury (SCI) leads to disruption of axonal architecture and macroscopic tissue loss with impaired information flow between the brain and spinal cord-the presumed basis of ensuing clinical impairment.Objective: The authors used a clinically viable, multimodal MRI pro...
| Publicado en: | Journal of Neurology, Neurosurgery & Psychiatry Vol. 83; no. 6; pp. 629 - 638 |
|---|---|
| Autores principales: | , , , , , , , , , , , , , , , |
| Formato: | research Journal Article |
| Publicado: |
BMJ Publishing Group
Jun2012
|
| Acceso en línea: | Ver este registro en EBSCOhost |
| fields | @attributes: recordID: 1 pdfLink: plink: https://search.ebscohost.com/login.aspx?direct=true&db=ccm&AN=104566673&site=ehost-live header: @attributes: shortDbName: ccm uiTerm: 104566673 longDbName: CINAHL Complete uiTag: AN controlInfo: bkinfo: dissinfo: jinfo: jid: 00223050 1Z1 jtl: Journal of Neurology, Neurosurgery & Psychiatry issn: 00223050 maglogo: N pubinfo: dt: Jun2012 vid: 83 iid: 6 pid: 8280 pub: BMJ Publishing Group artinfo: ui: 104566673 NLM22492214 2011548710 10.1136/jnnp-2011-301875 NLM22492214 PMC3348614 104566673 ppf: 629 ppct: 9 formats: tig: atl: Axonal integrity predicts cortical reorganisation following cervical injury. aug: au: Freund P Wheeler-Kingshott CA Nagy Z Gorgoraptis N Weiskopf N Friston K Thompson AJ Hutton C Freund, Patrick Wheeler-Kingshott, Claudia A Nagy, Zoltan Gorgoraptis, Nikos Weiskopf, Nikolaus Friston, Karl Thompson, Alan J Hutton, Chloe affil: Department of Brain Repair and Rehabilitation, UCL Institute of Neurology, London WC1N 3BG, UK sug: subj: Cerebral Cortex Physiopathology Nerve Fibers Pathology Nerve Fibers Physiology Neuroradiography Psychosocial Factors Spinal Cord Injuries Pathology Spinal Cord Injuries Physiopathology Adult Aged Case Control Studies Cervical Vertebrae Injuries Demyelinating Diseases Complications Demyelinating Diseases Pathology Demyelinating Diseases Physiopathology Human Magnetic Resonance Imaging Methods Magnetic Resonance Imaging Psychosocial Factors Male Middle Age Nerve Degeneration Pathology Nerve Degeneration Physiopathology Neural Pathways Pathology Neural Pathways Physiopathology Psychomotor Performance Adult: 19-44 years Aged: 65+ years Middle Aged: 45-64 years Male ab: Background: Traumatic spinal cord injury (SCI) leads to disruption of axonal architecture and macroscopic tissue loss with impaired information flow between the brain and spinal cord-the presumed basis of ensuing clinical impairment.Objective: The authors used a clinically viable, multimodal MRI protocol to quantify the axonal integrity of the cranial corticospinal tract (CST) and to establish how microstructural white matter changes in the CST are related to cross-sectional spinal cord area and cortical reorganisation of the sensorimotor system in subjects with traumatic SCI.Methods: Nine volunteers with cervical injuries resulting in bilateral motor impairment and 14 control subjects were studied. The authors used diffusion tensor imaging to assess white matter integrity in the CST, T1-weighted imaging to measure cross-sectional spinal cord area and functional MRI to compare motor task-related brain activations. The relationships among microstructural, macrostructural and functional measures were assessed using regression analyses. Results Diffusion tensor imaging revealed significant differences in the CST of SCI subjects-compared with controls-in the pyramids, the internal capsule, the cerebral peduncle and the hand area. The microstructural white matter changes observed in the left pyramid predicted increased task-related responses in the left M1 leg area, while changes in the cerebral peduncle were predicted by reduced cord area.Conclusion: The observed microstructural changes suggest trauma-related axonal degeneration and demyelination, which are related to cortical motor reorganisation and macrostructure. The extent of these changes may reflect the plasticity of motor pathways associated with cortical reorganisation. This clinically viable multimodal imaging approach is therefore appropriate for monitoring degeneration of central pathways and the evaluation of treatments targeting axonal repair in SCI. pubtype: Academic Journal doctype: research Journal Article ougenre: Article language: English refInfo: holdings: @attributes: islocal: N |
|---|