Reasons for and correlates of antiretroviral treatment interruptions in a cohort of patients from public and private clinics in southern India.
Understanding the prevalence and correlates of treatment interruptions (TIs) in resource-limited settings is important for improving adherence. HIV-infected adults on highly active antiretroviral therapy (HAART) in Bangalore, India, were enrolled into a prospective cohort study assessing HAART adher...
| Publicado en: | AIDS Care Vol. 24; no. 6; pp. 687 - 695 |
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| Autores principales: | , , , |
| Formato: | research tables/charts Journal Article |
| Publicado: |
Taylor & Francis Ltd
Jun2012
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| Acceso en línea: | Ver este registro en EBSCOhost |
| fields | @attributes: recordID: 1 pdfLink: plink: https://search.ebscohost.com/login.aspx?direct=true&db=ccm&AN=104568294&site=ehost-live header: @attributes: shortDbName: ccm uiTerm: 104568294 longDbName: CINAHL Complete uiTag: AN controlInfo: bkinfo: dissinfo: jinfo: jid: 09540121 AAE jtl: AIDS Care issn: 09540121 maglogo: N pubinfo: dt: Jun2012 vid: 24 iid: 6 pid: 377 pub: Taylor & Francis Ltd place: Philadelphia, Pennsylvania artinfo: ui: 104568294 75231915 10.1080/09540121.2011.630370 NLM22107044 104568294 ppf: 687 ppct: 8 formats: fmt: @attributes: type: P tig: atl: Reasons for and correlates of antiretroviral treatment interruptions in a cohort of patients from public and private clinics in southern India. aug: au: Vallabhaneni, Snigdha Chandy, Sara Heylen, Elsa Ekstrand, Maria affil: Center for AIDS Prevention Studies, University of California, San Francisco, CA, USA sug: subj: Anti-HIV Agents Antiretroviral Therapy, Highly Active Medication Compliance Human Odds Ratio Descriptive Statistics Antiretroviral Therapy, Highly Active Adverse Effects Confidence Intervals Viral Load CD4 Lymphocyte Count P-Value Adult Female Male India Chi Square Test Data Analysis Software Fisher's Exact Test Mann-Whitney U Test Adult: 19-44 years Female Male ab: Understanding the prevalence and correlates of treatment interruptions (TIs) in resource-limited settings is important for improving adherence. HIV-infected adults on highly active antiretroviral therapy (HAART) in Bangalore, India, were enrolled into a prospective cohort study assessing HAART adherence. Participants underwent a structured interview assessing adherence, including occurrence of TI > 48 hours since HAART initiation, length of TI, and self-reported reasons for TI. Serum HIV viral load (VL) and CD4 was measured at 6-month intervals. Baseline data are presented in this article. For the 552 participants mean age was 37.8, 32% were female, 70% were married, 45% earned < $2/day. Eighty-four percent were on nevirapine-based antiretroviral therapy; median duration on HAART was 18 months (range: 1–175) and median CD4 count was 318 cells/µl (IQR: 195–460) at time of study enrollment. Twenty percent (n=110) reported at least one TI; of these, 33% (n=36) reported more than one TI. Median length of most recent TI was 10 days (range: 2–1095). TI was associated with a higher probability of having VL > 400 copies/ml (43% versus 12%; p<0.001). After controlling for time on HAART, TI was more likely among those who were unmarried (OR: 1.9; CI: 1.2–3.1), those treated in a private clinic setting (OR: 2.7; CI: 1.6–4.6 compared with public, and OR: 4.1; CI: 1.9–9.0 compared with public–private setting), and those on efavirenz-based therapy (OR: 2.0; CI: 1.1–3.6). The most common self-reported reason for TI was “side effects” (n=28; 25%), followed by cost of therapy (n=24; 22%). We discuss implications for both individual and structural level interventions to reduce TIs. pubtype: Academic Journal doctype: research tables/charts Journal Article ougenre: Article language: English refInfo: holdings: @attributes: islocal: N |
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