A simulation technique for computation of the dosimetric effects of setup, organ motion and delineation uncertainties in radiotherapy.
In this study, we introduce a novel simulation technique to incorporate delineation errors into radiotherapy treatment margins and combine them with organ motion and set-up errors to investigate the cumulative dosimetric effects in different tumour sites. The effects of applying patient realignment...
| Publicado en: | Medical & Biological Engineering & Computing Vol. 48; no. 7; pp. 661 - 670 |
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| Autores principales: | , , , , , , , , , |
| Formato: | research Journal Article |
| Publicado: |
Springer Nature
Jul2010
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| Acceso en línea: | Ver este registro en EBSCOhost |
| fields | @attributes: recordID: 1 pdfLink: plink: https://search.ebscohost.com/login.aspx?direct=true&db=ccm&AN=104569236&site=ehost-live header: @attributes: shortDbName: ccm uiTerm: 104569236 longDbName: CINAHL Complete uiTag: AN controlInfo: bkinfo: dissinfo: jinfo: jid: 01400118 PO0 jtl: Medical & Biological Engineering & Computing issn: 01400118 maglogo: N pubinfo: dt: Jul2010 vid: 48 iid: 7 pid: 237 pub: Springer Nature place: New York, New York artinfo: ui: 104569236 NLM20414810 2010687581 10.1007/s11517-010-0616-z NLM20414810 104569236 ppf: 661 ppct: 9 formats: fmt: @attributes: type: P tig: atl: A simulation technique for computation of the dosimetric effects of setup, organ motion and delineation uncertainties in radiotherapy. aug: au: Mzenda B Hosseini-Ashrafi M Palmer A Liu H Brown DJ Mzenda, Bongile Hosseini-Ashrafi, Mir Palmer, Antony Liu, Honghai Brown, David J affil: Radiotherapy Physics Section, Medical Physics Department, Queen Alexandra Hospital, Portsmouth, PO6 3LY, UK sug: subj: Neoplasms Radiotherapy Radiotherapy, Computer-Assisted Methods Pilot Studies Male Systems Analysis Movement Radiometry Methods Radiation Dosage Male ab: In this study, we introduce a novel simulation technique to incorporate delineation errors into radiotherapy treatment margins and combine them with organ motion and set-up errors to investigate the cumulative dosimetric effects in different tumour sites. The effects of applying patient realignment correction protocols for radical treatments of prostate, lung and brain tumours were also modelled. Simulations were based on data from measurements using image-guidance techniques, including the use of fiducial markers in prostate and breathing correction techniques for the lung. The use of different sizes of planning target volume (PTV) margins was also evaluated. The prostate clinical target volumes' V99% showed up to 3.2% improvement with reduction in treatment uncertainties. For the lung plans, the V99% increased by up to an average of 10% with increase in treatment margin size from 0.5 to 1.5 cm. This improvement was, however, at the detriment of the dose delivered to the critical organs where the maximum dose received by the spinal cord increased by up to 0.5 Gy per fraction. These results were used to deduce the possible margin reductions and dose escalation achievable with reduced uncertainties. pubtype: Academic Journal doctype: research Journal Article ougenre: Article language: English refInfo: holdings: @attributes: islocal: N |
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