Multi-scale study of nanoparticle transport and deposition in tissues during an injection process.
In magnetic nanoparticle hyperthermia for cancer treatment, controlling the nanoparticle distribution delivered in tumors is vital for achieving an optimum distribution of temperature elevations that enables a maximum damage of the tumorous cells while minimizing the heating in the surrounding healt...
| Publicado en: | Medical & Biological Engineering & Computing Vol. 48; no. 9; pp. 853 - 864 |
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| Autores principales: | , , , , , , , |
| Formato: | research Journal Article |
| Publicado: |
Springer Nature
Sep2010
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| Acceso en línea: | Ver este registro en EBSCOhost |
| fields | @attributes: recordID: 1 pdfLink: plink: https://search.ebscohost.com/login.aspx?direct=true&db=ccm&AN=104569306&site=ehost-live header: @attributes: shortDbName: ccm uiTerm: 104569306 longDbName: CINAHL Complete uiTag: AN controlInfo: bkinfo: dissinfo: jinfo: jid: 01400118 PO0 jtl: Medical & Biological Engineering & Computing issn: 01400118 maglogo: N pubinfo: dt: Sep2010 vid: 48 iid: 9 pid: 237 pub: Springer Nature place: New York, New York artinfo: ui: 104569306 NLM20490947 2010755591 10.1007/s11517-010-0615-0 NLM20490947 104569306 ppf: 853 ppct: 11 formats: fmt: @attributes: type: P tig: atl: Multi-scale study of nanoparticle transport and deposition in tissues during an injection process. aug: au: Su D Ma R Salloum M Zhu L Su, Di Ma, Ronghui Salloum, Maher Zhu, Liang affil: Department of Mechanical Engineering, University of Maryland, Baltimore County, Baltimore, MD 21250, USA sug: subj: Hyperthermia, Induced Methods Models, Biological Nanotechnology Injections, Intralesional Nanotechnology Therapeutic Use Physics ab: In magnetic nanoparticle hyperthermia for cancer treatment, controlling the nanoparticle distribution delivered in tumors is vital for achieving an optimum distribution of temperature elevations that enables a maximum damage of the tumorous cells while minimizing the heating in the surrounding healthy tissues. A multi-scale model is developed in this study to investigate the spatial distribution of nanoparticles in tissues after nanofluid injection into the extracellular space of tissues. The theoretical study consists of a particle trajectory tracking model that considers particle-surface interactions and a macroscale model for the transport of nanoparticles in the carrier solution in a porous structure. Simulations are performed to examine the effects of a variety of injection parameters and particle properties on the particle distribution in tissues. The results show that particle deposition on the cellular structure is the dominant mechanism that leads to a non-uniform particle distribution. The particle penetration depth is sensitive to the injection rate and surface properties of the particles, but relatively insensitive to the injected volume and concentration of the nanofluid. pubtype: Academic Journal doctype: research Journal Article ougenre: Article language: English refInfo: holdings: @attributes: islocal: N |
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