Analysis of cell membrane permeabilization mechanics and pore shape due to ultrashort electrical pulsing.
Cell membrane permeabilization mechanics and the resulting shape of nanopores in response to electrical pulsing are probed based on a continuum approach. This has implications for electropermeabilization and cell membrane transport. It is argued that small pores resulting from high-intensity (approx...
| Publicado en: | Medical & Biological Engineering & Computing Vol. 48; no. 9; pp. 837 - 845 |
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| Autores principales: | , , , |
| Formato: | research Journal Article |
| Publicado: |
Springer Nature
Sep2010
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| Acceso en línea: | Ver este registro en EBSCOhost |
| fields | @attributes: recordID: 1 pdfLink: plink: https://search.ebscohost.com/login.aspx?direct=true&db=ccm&AN=104569315&site=ehost-live header: @attributes: shortDbName: ccm uiTerm: 104569315 longDbName: CINAHL Complete uiTag: AN controlInfo: bkinfo: dissinfo: jinfo: jid: 01400118 PO0 jtl: Medical & Biological Engineering & Computing issn: 01400118 maglogo: N pubinfo: dt: Sep2010 vid: 48 iid: 9 pid: 237 pub: Springer Nature place: New York, New York artinfo: ui: 104569315 NLM20635223 2010755599 10.1007/s11517-010-0659-1 NLM20635223 104569315 ppf: 837 ppct: 8 formats: fmt: @attributes: type: P tig: atl: Analysis of cell membrane permeabilization mechanics and pore shape due to ultrashort electrical pulsing. aug: au: Joshi RP Hu Q Joshi, Ravindra P Hu, Qin affil: Department of Electrical and Computer Engineering, Old Dominion University, Norfolk, VA 23529, USA sug: subj: Cell Physiology Cytological Techniques Methods Models, Biological Cell Membrane Electrophysiology Electromagnetic Fields Nanotechnology ab: Cell membrane permeabilization mechanics and the resulting shape of nanopores in response to electrical pulsing are probed based on a continuum approach. This has implications for electropermeabilization and cell membrane transport. It is argued that small pores resulting from high-intensity (approximately 100 kV/cm), nanosecond pulsing would have an initial asymmetric shape. This would lead to asymmetric membrane current-voltage characteristics, at least at early times. The role of the cytoskeleton is ignored here, but can be expected to additionally contribute to such asymmetries. Furthermore, we show that the pore shape and membrane conduction would be dynamic, and evolve toward a symmetric characteristic over time. This duration has been shown to be in the micro-second range. pubtype: Academic Journal doctype: research Journal Article ougenre: Article language: English refInfo: holdings: @attributes: islocal: N |
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