Microfluidics for cell separation.
The need for efficient cell separation, an essential preparatory step in many biological and medical assays, has led to the recent development of numerous microscale separation techniques. This review describes the current state-of-the-art in microfluidics-based cell separation techniques. Microflui...
| Publicado en: | Medical & Biological Engineering & Computing Vol. 48; no. 10; pp. 999 - 1015 |
|---|---|
| Autores principales: | , , , , , , , , , , , |
| Formato: | review Journal Article |
| Publicado: |
Springer Nature
Oct2010
|
| Acceso en línea: | Ver este registro en EBSCOhost |
| fields | @attributes: recordID: 1 pdfLink: plink: https://search.ebscohost.com/login.aspx?direct=true&db=ccm&AN=104569360&site=ehost-live header: @attributes: shortDbName: ccm uiTerm: 104569360 longDbName: CINAHL Complete uiTag: AN controlInfo: bkinfo: dissinfo: jinfo: jid: 01400118 PO0 jtl: Medical & Biological Engineering & Computing issn: 01400118 maglogo: N pubinfo: dt: Oct2010 vid: 48 iid: 10 pid: 237 pub: Springer Nature place: New York, New York artinfo: ui: 104569360 NLM20414811 2010799197 10.1007/s11517-010-0611-4 NLM20414811 104569360 ppf: 999 ppct: 16 formats: fmt: @attributes: type: P tig: atl: Microfluidics for cell separation. aug: au: Bhagat AA Bow H Hou HW Tan SJ Han J Lim CT Bhagat, Ali Asgar S Bow, Hansen Hou, Han Wei Tan, Swee Jin Han, Jongyoon Lim, Chwee Teck affil: BioSystems and Micromechanics (BioSyM) IRG, Singapore-MIT Alliance for Research and Technology (SMART) Centre, Singapore, Singapore sug: subj: Cell Separation Methods Microfluidics Methods Animals Flow Cytometry Methods ab: The need for efficient cell separation, an essential preparatory step in many biological and medical assays, has led to the recent development of numerous microscale separation techniques. This review describes the current state-of-the-art in microfluidics-based cell separation techniques. Microfluidics-based sorting offers numerous advantages, including reducing sample volumes, faster sample processing, high sensitivity and spatial resolution, low device cost, and increased portability. The techniques presented are broadly classified as being active or passive depending on the operating principles. The various separation principles are explained in detail along with popular examples demonstrating their application toward cell separation. Common separation metrics, including separation markers, resolution, efficiency, and throughput, of these techniques are discussed. Developing efficient microscale separation methods that offering greater control over cell population distribution will be important in realizing true point-of-care (POC) lab-on-a-chip (LOC) systems. pubtype: Academic Journal doctype: review Journal Article ougenre: Article language: English refInfo: holdings: @attributes: islocal: N |
|---|