Mathematical modeling of stem cell proliferation.
The mathematical models prevalently used to represent stem cell proliferation do not have the level of accuracy that might be desired. The hyperbolastic growth models promise a greater degree of precision in representing data of stem cell proliferation. The hyperbolastic growth model H3 is applied t...
| Publicado en: | Medical & Biological Engineering & Computing Vol. 49; no. 3; pp. 253 - 263 |
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| Autores principales: | , , , , , , , |
| Formato: | Journal Article |
| Publicado: |
Springer Nature
Mar2011
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| Acceso en línea: | Ver este registro en EBSCOhost |
| fields | @attributes: recordID: 1 pdfLink: plink: https://search.ebscohost.com/login.aspx?direct=true&db=ccm&AN=104570415&site=ehost-live header: @attributes: shortDbName: ccm uiTerm: 104570415 longDbName: CINAHL Complete uiTag: AN controlInfo: bkinfo: dissinfo: jinfo: jid: 01400118 PO0 jtl: Medical & Biological Engineering & Computing issn: 01400118 maglogo: N pubinfo: dt: Mar2011 vid: 49 iid: 3 pid: 237 pub: Springer Nature place: New York, New York artinfo: ui: 104570415 NLM20953843 2010967512 10.1007/s11517-010-0686-y NLM20953843 104570415 ppf: 253 ppct: 10 formats: fmt: @attributes: type: P tig: atl: Mathematical modeling of stem cell proliferation. aug: au: Tabatabai MA Bursac Z Eby WM Singh KP Tabatabai, Mohammad A Bursac, Zoran Eby, Wayne M Singh, Karan P affil: Department of Mathematical Sciences, Cameron University, 2800 W Gore Blvd., Lawton, OK 73505, USA sug: subj: Stem Cells Models, Biological Adult Cell Physiology Adult: 19-44 years ab: The mathematical models prevalently used to represent stem cell proliferation do not have the level of accuracy that might be desired. The hyperbolastic growth models promise a greater degree of precision in representing data of stem cell proliferation. The hyperbolastic growth model H3 is applied to experimental data in both embryonic stem cells and adult mesenchymal stem cells. In the embryonic stem cells the results are compared with other popular models, including the Deasy model, which is used prevalently for stem cell growth. In the case of modelling adult mesenchymal stem cells, H3 is also successfully applied to describe the proliferative index. We demonstrated that H3 can accurately represent the dynamics of stem cell proliferation for both embryonic and adult mesenchymal stem cells. We also recognize the importance of additional factors, such as cytokines, in determining the rate of growth. We propose the question of how to extend H3 to a multivariable model that can include the influence of growth factors. pubtype: Academic Journal doctype: Journal Article ougenre: Article language: English refInfo: holdings: @attributes: islocal: N |
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