An improved curvilinear gradient method for parameter optimization in complex biological models.
Mathematical modeling is an often used approach in biological science which, given some understanding of a system, is employed as a means of predicting future behavior and quantitative hypothesis testing. However, as our understanding of processes becomes more in depth, the models we use to describe...
| Publicado en: | Medical & Biological Engineering & Computing Vol. 49; no. 3; pp. 289 - 297 |
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| Autores principales: | , , , , , , , |
| Formato: | research Journal Article |
| Publicado: |
Springer Nature
Mar2011
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| Acceso en línea: | Ver este registro en EBSCOhost |
| fields | @attributes: recordID: 1 pdfLink: plink: https://search.ebscohost.com/login.aspx?direct=true&db=ccm&AN=104570416&site=ehost-live header: @attributes: shortDbName: ccm uiTerm: 104570416 longDbName: CINAHL Complete uiTag: AN controlInfo: bkinfo: dissinfo: jinfo: jid: 01400118 PO0 jtl: Medical & Biological Engineering & Computing issn: 01400118 maglogo: N pubinfo: dt: Mar2011 vid: 49 iid: 3 pid: 237 pub: Springer Nature place: New York, New York artinfo: ui: 104570416 NLM20676939 2010967510 10.1007/s11517-010-0667-1 NLM20676939 104570416 ppf: 289 ppct: 8 formats: fmt: @attributes: type: P tig: atl: An improved curvilinear gradient method for parameter optimization in complex biological models. aug: au: Szekely D Vandenberg JI Dokos S Hill AP Szekely, David Vandenberg, Jamie I Dokos, Socrates Hill, Adam P affil: Mark Cowley Lidwill Program in Cardiac Electrophysiology, Victor Chang Cardiac Research Institute, 405 Liverpool Street, Darlinghurst, NSW, 2010, Australia sug: subj: Signal Transduction Physiology Models, Biological Algorithms Carrier Proteins Physiology Heart Physiology Probability Cytological Techniques ab: Mathematical modeling is an often used approach in biological science which, given some understanding of a system, is employed as a means of predicting future behavior and quantitative hypothesis testing. However, as our understanding of processes becomes more in depth, the models we use to describe them become correspondingly more complex. There is a paucity of effective methods available for sampling the vast objective surfaces associated with complex multiparameter models while at the same time maintaining the accuracy needed for local evaluation of minima-all in a practical time period. We have developed a series of modifications to the curvilinear gradient method for parameter optimization. We demonstrate the power and efficiency of our routine through fitting of a 22 parameter Markov state model to an electrophysiological recording of a cardiac ion channel. Our method efficiently and accurately locates parameter minima which would not be easily identified using the currently available means. While the computational overhead involved in implementing the curvilinear gradient method may have contributed to resistance to adopting this technique, the performance improvements allowed by our modifications make this an extremely valuable tool in development of models of complex biological systems. pubtype: Academic Journal doctype: research Journal Article ougenre: Article language: English refInfo: holdings: @attributes: islocal: N |
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