Synergistic effects of local temperature enhancements on cellular responses in the context of high-intensity, ultrashort electric pulses.
Results of self-consistent analyses of cells show the possibility of temperature increases at membranes in response to a single nanosecond, high-voltage pulse, at least over small sections of the membrane. Molecular Dynamics simulations indicate that such a temperature increase could facilitate pora...
| Publicado en: | Medical & Biological Engineering & Computing Vol. 49; no. 6; pp. 713 - 719 |
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| Autores principales: | , , , , , |
| Formato: | research Journal Article |
| Publicado: |
Springer Nature
Jun2011
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| Acceso en línea: | Ver este registro en EBSCOhost |
| fields | @attributes: recordID: 1 pdfLink: plink: https://search.ebscohost.com/login.aspx?direct=true&db=ccm&AN=104572123&site=ehost-live header: @attributes: shortDbName: ccm uiTerm: 104572123 longDbName: CINAHL Complete uiTag: AN controlInfo: bkinfo: dissinfo: jinfo: jid: 01400118 PO0 jtl: Medical & Biological Engineering & Computing issn: 01400118 maglogo: N pubinfo: dt: Jun2011 vid: 49 iid: 6 pid: 237 pub: Springer Nature place: New York, New York artinfo: ui: 104572123 NLM21340640 2011162621 10.1007/s11517-011-0745-z NLM21340640 104572123 ppf: 713 ppct: 6 formats: fmt: @attributes: type: P tig: atl: Synergistic effects of local temperature enhancements on cellular responses in the context of high-intensity, ultrashort electric pulses. aug: au: Song J Joshi RP Schoenbach KH Song, J Joshi, R P Schoenbach, K H affil: Department of Electrical and Computer Engineering and Frank Reidy Center for Bio-Electrics, Old Dominion University, Norfolk, VA 23529-0246, USA sug: subj: Cytological Techniques Methods Cell Membrane Physiology Heat Membrane Potentials Physiology Models, Biological Time Factors ab: Results of self-consistent analyses of cells show the possibility of temperature increases at membranes in response to a single nanosecond, high-voltage pulse, at least over small sections of the membrane. Molecular Dynamics simulations indicate that such a temperature increase could facilitate poration, which is one example of a bio-process at the plasma membrane. Our study thus suggests that the use of repetitive high-intensity voltage pulses could open up possibilities for a host of synergistic bio-responses involving both thermal and electrically driven phenomena. pubtype: Academic Journal doctype: research Journal Article ougenre: Article language: English refInfo: holdings: @attributes: islocal: N |
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