NREM sleep staging using WAV(CNS) index.

Objective: Visual scoring of 30-s epochs of sleep data is not always adequate to show the dynamic structure of sleep in sufficient details. It is also prone to considerable inter- and intra-rater variability. Moreover, it involves considerable training and experience, and is very tedious, time-consu...

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Publicado en:Journal of Clinical Monitoring & Computing Vol. 25; no. 2; pp. 137 - 143
Autores principales: Agrawal G, Modarres M, Zikov T, Bibian S, Agrawal, Gracee, Modarres, Mohammad, Zikov, Tatjana, Bibian, Stephane
Formato: research Journal Article
Publicado: Springer Nature Apr2011
Acceso en línea:Ver este registro en EBSCOhost
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      dt: Apr2011
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      pub: Springer Nature
      place: New York, New York
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        atl: NREM sleep staging using WAV(CNS) index.
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        au:
          Agrawal G
          Modarres M
          Zikov T
          Bibian S
          Agrawal, Gracee
          Modarres, Mohammad
          Zikov, Tatjana
          Bibian, Stephane
        affil: NeuroWave Systems Inc., 2490 Lee Blvd, Suite 300, Cleveland Heights, OH 44118, USA
      sug:
        subj:
          Neurophysiology Methods
          Polysomnography Methods
          Sleep Physiology
          Sleep Stages Physiology
          Adolescence
          Adolescent Medicine Methods
          Algorithms
          Bar Coding
          Child
          Electroencephalography Methods
          Female
          Male
          Models, Statistical
          Retrospective Design
          Adolescent: 13-18 years
          Child: 6-12 years
          Female
          Male
      ab: Objective: Visual scoring of 30-s epochs of sleep data is not always adequate to show the dynamic structure of sleep in sufficient details. It is also prone to considerable inter- and intra-rater variability. Moreover, it involves considerable training and experience, and is very tedious, time-consuming, labor-intensive and costly. Hence, automatic sleep staging is needed to overcome these limitations. Since naturally occurring NREM sleep and anesthesia have been reported to possess various underlying neurophysiological similarities, EEG-based depth-of-anesthesia monitors have started to penetrate into sleep research. This study investigates the ability of WAV(CNS) index (as implemented in NeuroSENSE depth-of-anesthesia monitor) to detect NREM sleep stages and wake state for full overnight PSG data.Methods: Full overnight PSG sleep data, obtained from 24 adolescents, was scored by a registered PSG technologist for different sleep stages. Retrospective analysis was performed on a single frontal channel using the WAV(CNS) algorithm. Non-parametric descriptive statistics were used to examine the relationship between WAV(CNS) index and sleep stages.Results: A strong correlation (ρ = 0.9458) was found between the WAV(CNS) index and NREM sleep stages, with WAV(CNS) index values decreasing with increasing sleep stages. Moreover, there was no significant overlap between different NREM sleep stages as classified by the WAV(CNS) index, which was able to significantly differentiate (P < 0.001) between all pairs of Awake and different NREM stages.Conclusions: This study demonstrates that changes in the depth of natural NREM sleep are reflected sensitively by changes in the WAV(CNS) index. Hence, WAV(CNS) index may serve as an automatic real-time indicator of depth of natural sleep with high temporal resolution, and can possibly be of great use for automated sleep staging in routine/postoperative somnographic studies.
      pubtype: Academic Journal
      doctype:
        research
        Journal Article
      ougenre: Article
    language: English
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