Incremental value of diffusion weighted and dynamic contrast enhanced MRI in the detection of locally recurrent prostate cancer after radiation treatment: preliminary results.
Objectives: To assess the incremental value of diffusion-weighted (DW-MRI) and dynamic contrast-enhanced MRI (DCE-MRI) to T2-weighted MRI (T2WI) in detecting locally recurrent prostate cancer after radiotherapy.Methods: Twenty-four patients (median age, 70 years) with a history of radiotherapy-treat...
| Publicado en: | European Radiology Vol. 21; no. 9; pp. 1970 - 1979 |
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| Autores principales: | , , , , , , , , , , , , , , , , , , , |
| Formato: | research Journal Article |
| Publicado: |
Springer Nature
Sep2011
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| Acceso en línea: | Ver este registro en EBSCOhost |
| fields | @attributes: recordID: 1 pdfLink: plink: https://search.ebscohost.com/login.aspx?direct=true&db=ccm&AN=104576170&site=ehost-live header: @attributes: shortDbName: ccm uiTerm: 104576170 longDbName: CINAHL Complete uiTag: AN controlInfo: bkinfo: dissinfo: jinfo: jid: 09387994 NPH jtl: European Radiology issn: 09387994 maglogo: N pubinfo: dt: Sep2011 vid: 21 iid: 9 pid: 237 pub: Springer Nature place: New York, New York artinfo: ui: 104576170 63882448 NLM21533634 2011237674 10.1007/s00330-011-2130-6 NLM21533634 PMC3730825 104576170 ppf: 1970 ppct: 9 formats: fmt: – @attributes: type: T – @attributes: type: P tig: atl: Incremental value of diffusion weighted and dynamic contrast enhanced MRI in the detection of locally recurrent prostate cancer after radiation treatment: preliminary results. aug: au: Akin O Gultekin DH Vargas HA Zheng J Moskowitz C Pei X Sperling D Schwartz LH Hricak H Zelefsky MJ Akin, Oguz Gultekin, David H Vargas, Hebert Alberto Zheng, Junting Moskowitz, Chaya Pei, Xin Sperling, Dahlia Schwartz, Lawrence H Hricak, Hedvig Zelefsky, Michael J affil: Department of Radiology, Memorial Sloan-Kettering Cancer Center, 1275 York Avenue, New York, NY 10065, USA sug: subj: Magnetic Resonance Imaging Methods Image Interpretation, Computer Assisted Neoplasm Recurrence, Local Diagnosis Prostatic Neoplasms Radiotherapy Aged Biopsy, Needle Prospective Studies Evaluation Research Contrast Media Diagnostic Use Immunohistochemistry Male Middle Age Neoplasm Invasiveness Pathology Neoplasm Recurrence, Local Pathology Neoplasm Staging Prostatic Neoplasms Pathology Reference Values Reproducibility of Results Retrospective Design Sensitivity and Specificity Aged: 65+ years Middle Aged: 45-64 years Male ab: Objectives: To assess the incremental value of diffusion-weighted (DW-MRI) and dynamic contrast-enhanced MRI (DCE-MRI) to T2-weighted MRI (T2WI) in detecting locally recurrent prostate cancer after radiotherapy.Methods: Twenty-four patients (median age, 70 years) with a history of radiotherapy-treated prostate cancer underwent multi-parametric MRI (MP-MRI) and transrectal prostate biopsy. Two readers independently scored the likelihood of cancer on a 1-5 scale, using T2WI alone and then adding DW-MRI and DCE-MRI. Areas under receiver operating characteristic curves (AUCs) were estimated at the patient and prostate-side levels. The apparent diffusion coefficient (ADC) from DW-MRI and the K(trans), k(ep), v(e), AUGC90 and AUGC180 from DCE-MRI were recorded.Results: Biopsy was positive in 16/24 (67%) and negative in 8/24 (33%) patients. AUCs for readers 1 and 2 increased from 0.64 and 0.53 to 0.95 and 0.86 with MP-MRI, at the patient level, and from 0.73 and 0.66 to 0.90 and 0.79 with MP-MRI, at the prostate-side level (p values < 0.05). Biopsy-positive and biopsy-negative prostate sides differed significantly in median ADC [1.44 vs. 1.68 (×10(-3) mm(2)/s)], median K(trans) [1.07 vs. 0.34 (1/min)], and k(ep) [2.06 vs 1.0 (1/min)] (p values < 0.05).Conclusions: MP-MRI was significantly more accurate than T2WI alone in detecting locally recurrent prostate cancer after radiotherapy. pubtype: Academic Journal doctype: research Journal Article ougenre: Article language: English refInfo: holdings: @attributes: islocal: N |
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