Transient elastography for assessment of fibrosis in paediatric liver disease.
The prognosis and management of chronic liver diseases in children largely depend on the extent and progression of liver fibrosis, which is often the most important predictor of disease outcome, and thus influences the indication for potential therapy. Unfortunately, liver biopsy continues to be the...
| Publicado en: | Pediatric Radiology Vol. 41; no. 10; pp. 1232 - 1239 |
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| Autores principales: | , , , , , , , , , , , |
| Formato: | review Journal Article |
| Publicado: |
Springer Nature
Oct2011
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| Acceso en línea: | Ver este registro en EBSCOhost |
| fields | @attributes: recordID: 1 pdfLink: plink: https://search.ebscohost.com/login.aspx?direct=true&db=ccm&AN=104581157&site=ehost-live header: @attributes: shortDbName: ccm uiTerm: 104581157 longDbName: CINAHL Complete uiTag: AN controlInfo: bkinfo: dissinfo: jinfo: jid: 03010449 O03 jtl: Pediatric Radiology issn: 03010449 maglogo: N pubinfo: dt: Oct2011 vid: 41 iid: 10 pid: 237 pub: Springer Nature place: New York, New York artinfo: ui: 104581157 NLM21678114 2011271738 10.1007/s00247-011-2143-y NLM21678114 104581157 ppf: 1232 ppct: 7 formats: fmt: @attributes: type: P tig: atl: Transient elastography for assessment of fibrosis in paediatric liver disease. aug: au: Nobili V Monti L Alisi A Zupone CL Pietrobattista A Tomà P Nobili, Valerio Monti, Lidia Alisi, Anna Lo Zupone, Cristina Pietrobattista, Andrea Tomà, Paolo affil: Liver Unit, Research Institute, Bambino Gesù Children's Hospital, Piazza S Onofrio 4, 00165 Rome, Italy sug: subj: Ultrasonography Methods Fatty Liver Ultrasonography Liver Cirrhosis Ultrasonography Biopsy Child Disease Progression Magnetic Resonance Imaging Child: 6-12 years ab: The prognosis and management of chronic liver diseases in children largely depend on the extent and progression of liver fibrosis, which is often the most important predictor of disease outcome, and thus influences the indication for potential therapy. Unfortunately, liver biopsy continues to be the gold standard for the staging and grading of fibrosis. Liver biopsy is an invasive and painful technique with several limitations. These limitations have led to the development of alternative noninvasive methods for the accurate assessment of fibrosis and for the maintenance of an acceptable risk/benefit ratio. In the last decades, transient elastography (TE) has received increasing consideration as a means of evaluating disease progression in paediatric chronic liver disease. TE is an accurate and reproducible methodology for identifying subjects without fibrosis or significant fibrosis, or with advanced fibrosis. In this review, we provide an outline of liver fibrosis in paediatric liver diseases, including fibrogenesis, and noninvasive techniques for the diagnosis and follow-up of fibrosis, and then focus on the characteristics of TE and on its strength in the assessment of liver fibrosis, paying particular attention to studies conducted in children. pubtype: Academic Journal doctype: review Journal Article ougenre: Article language: English refInfo: holdings: @attributes: islocal: N |
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