Quantitative assessment of liver fat with magnetic resonance imaging and spectroscopy.
Hepatic steatosis is characterized by abnormal and excessive accumulation of lipids within hepatocytes. It is an important feature of diffuse liver disease, and the histological hallmark of nonalcoholic fatty liver disease (NAFLD). Other conditions associated with steatosis include alcoholic liver d...
| Publicado en: | Journal of Magnetic Resonance Imaging Vol. 34; no. 4; pp. 729 - 750 |
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| Autores principales: | , , , , , , , |
| Formato: | research Journal Article |
| Publicado: |
Wiley-Blackwell
Oct2011
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| Acceso en línea: | Ver este registro en EBSCOhost |
| fields | @attributes: recordID: 1 pdfLink: plink: https://search.ebscohost.com/login.aspx?direct=true&db=ccm&AN=104582688&site=ehost-live header: @attributes: shortDbName: ccm uiTerm: 104582688 longDbName: CINAHL Complete uiTag: AN controlInfo: bkinfo: dissinfo: jinfo: jid: 10531807 O63 jtl: Journal of Magnetic Resonance Imaging issn: 10531807 maglogo: Y pubinfo: dt: Oct2011 vid: 34 iid: 4 pid: 480 pub: Wiley-Blackwell place: Malden, Massachusetts artinfo: ui: 104582688 65494492 65494492 10.1002/jmri.22580 NLM21928307 104582688 ppf: 729 ppct: 21 formats: tig: atl: Quantitative assessment of liver fat with magnetic resonance imaging and spectroscopy. aug: au: Reeder SB Cruite I Hamilton G Sirlin CB Reeder, Scott B Cruite, Irene Hamilton, Gavin Sirlin, Claude B affil: Liver Imaging Research Program, Department of Radiology, University of Wisconsin, Madison, Wisconsin, USA sug: subj: Fatty Liver Diagnosis Liver Pathology Magnetic Resonance Imaging Methods Magnetic Resonance Spectroscopy Methods Diagnostic Imaging Methods Fatty Liver Pathology Female Liver Radiography Liver Ultrasonography Male Sensitivity and Specificity Severity of Illness Indices Tomography, X-Ray Computed Methods Ultrasonography, Doppler Methods Female Male ab: Hepatic steatosis is characterized by abnormal and excessive accumulation of lipids within hepatocytes. It is an important feature of diffuse liver disease, and the histological hallmark of nonalcoholic fatty liver disease (NAFLD). Other conditions associated with steatosis include alcoholic liver disease, viral hepatitis, human immunodeficiency virus (HIV) and genetic lipodystrophies, cystic fibrosis liver disease, and hepatotoxicity from various therapeutic agents. Liver biopsy, the current clinical gold standard for assessment of liver fat, is invasive and has sampling errors, and is not optimal for screening, monitoring, clinical decision-making, or well suited for many types of research studies. Noninvasive methods that accurately and objectively quantify liver fat are needed. Ultrasound (US) and computed tomography (CT) can be used to assess liver fat but have limited accuracy as well as other limitations. Magnetic resonance (MR) techniques can decompose the liver signal into its fat and water signal components and therefore assess liver fat more directly than CT or US. Most MR techniques measure the signal fat-fraction (the fraction of the liver MR signal attributable to liver fat), which may be confounded by numerous technical and biological factors and may not reliably reflect fat content. By addressing the factors that confound the signal fat-fraction, advanced MR techniques measure the proton density fat-fraction (the fraction of the liver proton density attributable to liver fat), which is a fundamental tissue property and a direct measure of liver fat content. These advanced techniques show promise for accurate fat quantification and are likely to be commercially available soon. pubtype: Academic Journal doctype: research Journal Article ougenre: Article language: English refInfo: holdings: @attributes: islocal: N |
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