Sodium butyrate inhibits pathogenic yeast growth and enhances the functions of macrophages.
Objectives: Butyrate is a short-chain fatty acid that is produced by several human commensal bacteria, such as Clostridium and Lactobacillus species. Butyrate is also known to inhibit histone deacetylase. In this study we assessed the antifungal activity of sodium butyrate (SB) against the human pat...
| Publicado en: | Journal of Antimicrobial Chemotherapy (JAC) Vol. 66; no. 11; pp. 2573 - 2581 |
|---|---|
| Autores principales: | , , , , , , , |
| Formato: | research Journal Article |
| Publicado: |
Oxford University Press / USA
Nov2011
|
| Acceso en línea: | Ver este registro en EBSCOhost |
| fields | @attributes: recordID: 1 pdfLink: plink: https://search.ebscohost.com/login.aspx?direct=true&db=ccm&AN=104588578&site=ehost-live header: @attributes: shortDbName: ccm uiTerm: 104588578 longDbName: CINAHL Complete uiTag: AN controlInfo: bkinfo: dissinfo: jinfo: jid: 03057453 N5O jtl: Journal of Antimicrobial Chemotherapy (JAC) issn: 03057453 maglogo: N pubinfo: dt: Nov2011 vid: 66 iid: 11 pid: 622 pub: Oxford University Press / USA artinfo: ui: 104588578 NLM21911344 2011319354 10.1093/jac/dkr358 NLM21911344 104588578 ppf: 2573 ppct: 8 formats: tig: atl: Sodium butyrate inhibits pathogenic yeast growth and enhances the functions of macrophages. aug: au: Nguyen LN Lopes LC Cordero RJ Nosanchuk JD Nguyen, Long Nam Lopes, Livia Cristina Liporagi Cordero, Radames J B Nosanchuk, Joshua D affil: Department of Medicine, Albert Einstein College of Medicine, Bronx, NY, USA sug: subj: Antifungal Agents Pharmacodynamics Butyric Acids Pharmacodynamics Candida Albicans Drug Effects Cryptococcus Drug Effects Macrophages Metabolism Heterocyclic Compounds Pharmacodynamics Biofilms Drug Effects Candida Albicans Clostridium Metabolism Cryptococcus Enzyme Inhibitors Pharmacodynamics Lactobacillus Metabolism Macrophages Immunology Macrophages Microbiology Microbial Culture and Sensitivity Tests Nitric Oxide Phagocytosis Drug Effects Phenotype Reactive Oxygen Species Metabolism ab: Objectives: Butyrate is a short-chain fatty acid that is produced by several human commensal bacteria, such as Clostridium and Lactobacillus species. Butyrate is also known to inhibit histone deacetylase. In this study we assessed the antifungal activity of sodium butyrate (SB) against the human pathogenic yeasts Candida albicans, Candida parapsilosis and Cryptococcus neoformans.Methods: The growth and virulence traits of the yeasts were assayed in vitro and during interaction with macrophages in the presence of SB.Results: SB strongly inhibited yeast growth in a concentration-dependent manner, inhibited virulence traits such as filamentation in C. albicans and melanization and capsule formation in C. neoformans and, importantly, significantly decreased yeast biofilm formation. SB also enhanced the antifungal activity of azole drugs. Notably, SB augmented the antifungal activity of macrophages by enhancing the production of reactive oxygen species. The phagocytic rate and killing activity of macrophages significantly increased in the presence of SB, which coincided with an increase in nitric oxide production.Conclusions: These results demonstrate that SB exerts significant antifungal activity on pathogenic yeasts and enhances the antimicrobial actions of macrophages in response to these microbes. pubtype: Academic Journal doctype: research Journal Article ougenre: Article language: English refInfo: holdings: @attributes: islocal: N |
|---|